ORIGINAL ARTICLES: EpidemiologyPrimary malignant melanoma at unusual sites: an institutional experience with review of literatureDas, Prasenjit; Kumar, Narender; Ahuja, Arvind; Jain, Ayushi; Ray, Ruma; Sarkar, Chitra; Gupta, Siddhartha DattaAuthor Information Department of Pathology, All India Institute of Medical Sciences, New Delhi, India Correspondence to Dr Siddhartha Datta Gupta, MD, Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India Tel: +91 11 9868397193; fax: +91 11 26588663 e-mail: email@example.com; firstname.lastname@example.org Received 15 October 2009 Accepted 22 October 2009 Melanoma Research: June 2010 - Volume 20 - Issue 3 - p 233-239 doi: 10.1097/CMR.0b013e328334c39a Buy Metrics Abstract Apart from the skin and choroid plexus, primary malignant melanoma is rare at the other sites and lacks organized documentation. Here, we have tried to enumerate the primary malignant melanomas at various atypical sites, supported by literature review. Seventeen cases were identified from our records of the past 5 years, which had detailed clinical work-up to exclude a possibility of a metastasis. A clear female predominance with involvement of the lower genitourinary tract was identified. In addition to three cases from the vagina, two cases each from the cervix, ovary and urethra, respectively, such cases were also identified in cerebral cortex (frontal and fronto-parietal area), rectum, nasal cavity, tongue, breast and tonsillar fossa. Although many were amelanotic, no specific histology was noted. In conclusion, malignant melanomas can arise in unconventional areas. Gross tumor appearance and the unavailability of an immunohistochemical panel, may result in their misdiagnosis as primary epithelial malignancies. A possible metastasis should always be ruled out. © 2010 Lippincott Williams & Wilkins, Inc.