The purpose of this study was to assess the precision of automatic computerized measurement of parameters that may be useful in the differentiation of malignant melanoma from benign pigmented skin lesions, and also to determine the feasibility of quantitative monitoring of skin lesions over time. Ten independent sequences of images were acquired with a MelaFind multispectral digital dermoscope for each of 12 benign or malignant pigmented skin lesions. The sequences of images were processed automatically to provide 10 independent measurements of the various parameters for each lesion. Parameters included lesion area, greatest ‘diameter', perimeter, reflectance and asymmetry. The precision of each parameter determination was computed from the mean and standard deviation of the 10 measurements of that parameter. The relative errors in determining the lesion area, ‘diameter’ and perimeter were found to be 6%, 3% and 4%, respectively. Other lesion parameters that are used in differentiating melanomas from benign skin lesions were also analysed as a function of wavelength. In the blue band (about 430 nm) the relative error was about 7% for the mean lesion reflectance and about 7% for the asymmetry parameter. These results demonstrate the feasibility of using MelaFind for objective quantitative monitoring of changes in pigmented skin lesions over time. As suggested by some studies, such information is useful in the early detection of malignant melanoma. The results show that parameters obtained automatically from MelaFind images are sufficiently precise to allow pertinent parameters to be used to classify pigmented skin lesions.
Electro-Optical Sciences, Inc., 1 Bridge Street, Irvington, NY 10533, USA. Tel: (+1) 914 591 3783; Fax: (+1) 914 591 3785 (D. Gutkowicz-Krusin, M. Elbaum, A. Jacobs, S. Keem). The Ronald O. Perelman Department of Dermatology, New York University Medical Center, NY 10016, USA (A. W. Kopf, H. Kamino, S. Wang, P. Rubin). Skin and Cancer Associates, 201 N.W. 82nd Avenue, Bennett Medical Plaza, Suite 501, Plantation, FL 33324, USA (H. Rabinovitz, M. Oliviero).
(Received 20 October 1999; accepted in revised form 21 February 2000)
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