Original Articles: PDF OnlyMultiple agminate Spitz naeviHulshof, M. M.; van Haeringen, A.; Gruis, N. A.; Snels, D. C. G. T. M.; Bergman, W.Author Information Departments of Dermatology (M. M. Hulshof, D. C. G. T. M. Snels, W. Bergman) and Clinical Genetics (A. van Haeringen), University Hospital Leiden, PO Box 9600, 2300 RC Leiden, The Netherlands. Tel: (+31) 71 526 2497; Fax: (+31) 71 524 8106. Department of Human Genetics (N. A. Gruis), University Leiden, The Netherlands Melanoma Research: April 1998 - Volume 8 - Issue 2 - p 156-160 Buy Abstract We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed. © Lippincott-Raven Publishers.