ORIGINAL ARTICLES: PDF OnlyCytokines in human melanoma cells synthesis, autocrine stimulation and regulatory functions—an overviewKrasagakis, K.; Garbe, C.; Orfanos, C. E.Author Information Department of Dermatology, University Medical Center Steglitz, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany. Tel: (+49) 30 798 2319/2770; Fax: (+49) 30 798 4141. Melanoma Research: November 1993 - Volume 3 - Issue 6 - p 425-434 Buy Abstract Various cytokines are involved in growth regulation of human melanoma cells. Malignant melanoma cells express multiple growth factors, including basic fibroblast growth factor (bFGF), transforming growth factor (TGF)-α, platelet-derived growth factor (PDGF)-α, and melanoma growth stimulatory activity (MGSA), substances which are not expressed in normal human melanocytes. The simultaneous synthesis of growth factors and expression of their receptors by melanoma cells, leading to permanent stimulation of cell proliferation, has been clearly shown for bFGF and MGSA. This phenomenon has been designated autocrine growth stimulation. Increased or altered expression of growth factor receptors has been described for nerve growth factor (NGF) receptor, for PDGF-β receptor and for a truncated form of epidermal growth factor (EGF) receptor encoded by the c-ero-B2 oncogene. Lymphoklnes are mainly Involved in growth control of melanoma cells. Interferons (IFN)-α,-α and-ν, Interleukins (IL)-1 and −6 as well as tumour necrosis factor (TNF)-α, Inhibited melanoma cell proliferation, with the strongest effects displayed by IFN. TGF-β which was found to inhibit proliferation of normal human melanocytes exhibited marginal effects on melanoma cells, or even stimulated their growth. In conclusion, a complex network of cytokines Is Involved In the regulation of melanoma cell growth. Further insight into these mechanisms may contribute to the finding of new strategies in melanoma therapy. © Lippincott-Raven Publishers.