Article: PDF OnlyThe prognostic significance of histologic regression in cutaneous melanomaBrogelli, L.; Umberto, M. R.; Moretti, S.; Urso, C.Author Information Chirurgia Plastica e Ricostruttiva, University of Firenze, Italy (M. R. Umberto); Clinica Dermatologica II, University of Firenze, via della Pergola 58, 50121 Firenze, Italy, Fax: 055/2478356 (L. Brogelli, S. Moretti); Istituto Anatomia e Istologia Patologica, University of Firenze, Italy (C. Urso). Melanoma Research: July 1992 - Volume 2 - Issue 2 - p 87-92 Buy Abstract A retrospective evaluation of 201 stage I cutaneous melanomas was performed to Investigate the prognostic significance of histological regression (present in 67 cases). Thin melanomas showed regression more frequently than thick lesions (48% ≤ 0.75 mm vs 12% < 3 mm). The mean disease-free Interval was 33.53 months in regressing tumours and 19.9 in non-regressing tumours (p = 0.07): differences between the survival curves were not significant (p = 0.61). Metastases developed in 13 (19.40%) patients with regressing tumours and by 40 (29.85%) patients with non-regressing tumours. Although we observed a higher frequency of regression in thin melanomas we could not demonstrate an influence of regression on disease-free interval and survival. © Lippincott-Raven Publishers.