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The scope of orodental genetics

ElHadidi, Sahar M.a; Aboul-Ezz, Eman H.a; ElBadry, Tarek H.b; Temtamy, Samia A.c

Middle East Journal of Medical Genetics: July 2017 - Volume 6 - Issue 2 - p 49–60
doi: 10.1097/01.MXE.0000521017.17904.8f
Review article

The mouth is the mirror of a person’s body, and the facial complex reflects the genetic profile. The head and face present complex morphology. Genetic factors determine the morphology of the face, teeth, jaw, palate, and many of the salivary constituents and resistance to caries and periodontal disease. Congenital malformations of the head and neck are common. Orofacial anomalies are the most common forms of birth defects. Many resolve spontaneously shortly after birth, and others persist. They represent considerable variability among individuals affected by the same disorder. They constitute personal, familial, and social burdens, owing to the disfigurement itself, and the associated negative feeling and isolation. They need meticulous evaluation, to plan interventions, geared toward preventing consequences. Orodental geneticists emphasize a major role of these interventions in contributing to the health of medically compromised children. These involve differentiating between clinically normal and abnormal phenotypes. Such differentiation can identify patients at risk, and guide the physicians in the accurate diagnosis, and in the application of advancing research in gene, cell, and protein therapies, to regenerate damaged tissue and teeth. Developmental disturbances peculiar to the head and neck establish the foundation of the craniofacial-dysmorphology field. This review tends to explore some aspects of the orodental-genetic discipline.

Departments of aBasic Dental Science

bOro-Dental Genetics

cClinical Genetics, National Research Center, Cairo, Egypt

Correspondence to Sahar M. ElHadidi, PhD, Department of Basic Dental Science, National Research Center, 33 El-Bohooth Street, Dokki, 12311 Cairo, Egypt Tel: +20 233 389 438; fax: +20 233 370 931; e-mail: dr-sahar-elhadidi@hotmail.com

Received May 3, 2017

Accepted July 9, 2017

© 2017 Middle East Journal of Medical Genetics
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