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Impact of lifestyle and psychological stress on the development of early onset breast cancer

Section Editor(s): Cheng., XiwenLi, Ping RNa,b; Huang, Jialing RNa,b; Wu, Huina RNa,b; Fu, Cuixia RNa,b; Li, Yun RNa,b; Qiu, Jiajia MSN, RNa,b,*

doi: 10.1097/MD.0000000000005529
Research Article: Observational Study

The present study aimed to investigate risk factors for early onset breast cancer that are related to lifestyle and psychological stress. A comparative case–control study was performed among patients from the Department of Breast Surgery in Shanghai Cancer Center of Fudan University. The information regarding risk factors associated with the development of early onset breast cancer was collected using a questionnaire in a face-to-face interview. The distribution of the risk factors associated with the development of early onset breast cancer between the patient group and the control group was analyzed with logistic regression. A total of 582 cases of young patients (≤40 years old) with breast cancer and 540 controls of young patients (≤40 years old) with benign breast disease were included in this study. The risk factors for breast cancer in young women include age at first birth (odds ratio [OR] = 0.93, 95% confidence interval [CI]: 0.88–0.98), history of breast cancer in an immediate family member (OR = 2.36, 95% CI: 1.14–4.89), history of genital surgery (OR = 2.11, 95% CI: 1.16–3.82), active and passive smoking in daily life or the environment (OR = 1.64, 95% CI: 1.19–2.25), weekly intake of soy products (OR = 1.24, 95% CI: 1.02–1.49), use of household cooking oil (OR = 2.04, 95% CI: 1.04–4.00), disharmonious marital status (OR = 1.16, 95% CI: 1.06–1.26), frequent depression (OR = 1.32, 95% CI: 1.00–1.75), and negative emotional experiences (OR = 1.15, 95% CI: 1.03–1.29). Our study could provide the basis for risk assessment and preventive interventions for early onset breast cancer.

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aDepartment of Nursing Administration, Shanghai Cancer Center

bDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Correspondence: Jiajia Qiu, Department of Nursing Administration, Shanghai Cancer Center, Fudan University, Shanghai 200032, China (e-mail: rainmouse@hotmail.com).

Abbreviations: CI = confidence interval, OR = odds ratio, PSSG = Psychosocial Stress Survey for Groups.

The authors have no conflicts of interest to disclose.

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Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.md-journal.com).

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

Received June 13, 2016

Received in revised form October 24, 2016

Accepted November 10, 2016

Copyright © 2016 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.