A cerebral AVM is an abnormal connection between the arteries and veins in the brain, consisting of a nidus, arterial feeders, and draining veins.[1,3] Its incidence is 0.9 to 1.4 per 100,000 person-years.[3,6] Patients typically present with the symptoms caused by intracerebral hemorrhage or steal syndrome.[4,10–12] The size of the nidus typically increases with time, and although spontaneous obliteration is rare, it can occur in <1.5% of all cerebral AVMs.[3,13,14]
. Jin Y, Zou Y, Hua C, et al. Treatment of early-stage extracranial arteriovenous malformations with intralesional interstitial bleomycin injection: a pilot study. Radiology 2018;287:194–204.
. Couto JA, Huang AY, Konczyk DJ, et al. Somatic MAP2K1 mutations are associated with extracranial arteriovenous malformation. Am J Hum Genet 2017;100:546–54.
. Panciani PP, Fontanella M, Carlino C, et al. Progressive spontaneous occlusion of a cerebellar AVM: pathogenetic hypothesis and review of literature. Clin Neurol Neurosurg 2008;110:502–10.
. van Beijnum J, van der Worp H, Buis D, et al. Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA 2011;306:2011–9.
. Kim H, Su H, Weinsheimer S, et al. Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. Acta Neurochir Suppl 2011;111:83–92.
. Ozpinar A, Mendez G, Abla AA. Epidemiology, genetics, pathophysiology, and prognostic classifications of cerebral arteriovenous malformations. Handb Clin Neurol 2017;143:5–13.
. Stapf C, Labovitz DL, Sciacca RR, et al. Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey. Cerebrovasc Dis 2002;13:43–6.
. Cao C, Sourour N, Reina V, et al. Spontaneous thrombosis of the main draining vein revealing an unruptured brain arteriovenous malformation. Interv Neuroradiol 2015;21:222–6.
. Sawlani V, Handique A, Phadke RV. Spontaneous regression of cerebral AVM due to thrombosis of draining vein--angiographic and MRI demonstration. J Neurol Sci 2004;223:195–8.
. Kim BS, Sarma D, Lee SK, et al. Brain edema associated with unruptured brain arteriovenous malformations. Neuroradiology 2009;51:327–35.
. Brown RD Jr, Wiebers DO, Torner JC, et al. Frequency of intracranial hemorrhage as a presenting symptom and subtype analysis: a population-based study of intracranial vascular malformations in Olmsted Country, Minnesota. J Neurosurg 1996;85:29–32.
. Ogilvy CS, Stieg PE, Awad I, et al. AHA Scientific Statement: recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association. Stroke 2001;32:1458–71.
. Patel MC, Hodgson TJ, Kemeny AA, et al. Spontaneous obliteration
of pial arteriovenous malformations: a review of 27 cases. AJNR Am J Neuroradiol 2001;22:531–6.
. Abdulrauf SI, Malik GM, Awad IA. Spontaneous angiographic obliteration of cerebral arteriovenous malformations. Neurosurgery 1999;44:280–7. discussion 287-288.
. Enam SA, Malik GM. Association of cerebral arteriovenous malformations and spontaneous occlusion of major feeding arteries
: clinical and therapeutic implications. Neurosurgery 1999;45:1105–11. discussion 1111-1102.
. Kurita H, Shin M, Ueki K, et al. Congestive brain oedema associated with a pial arteriovenous malformation with impaired venous drainage. Acta Neurochir (Wien) 2001;143:339–42.
. Krapf H, Siekmann R, Freudenstein D, et al. Spontaneous occlusion of a cerebral arteriovenous malformation: angiography and MR imaging follow-up and review of the literature. AJNR Am J Neuroradiol 2001;22:1556–60.
. Cronqvist M, Wirestam R, Ramgren B, et al. Endovascular treatment of intracerebral arteriovenous malformations: procedural safety, complications, and results evaluated by MR imaging, including diffusion and perfusion imaging. AJNR Am J Neuroradiol 2006;27:162–76.
. Picard L, Da Costa E, Anxionnat R, et al. Acute spontaneous hemorrhage after embolization of brain arteriovenous malformation with N-butyl cyanoacrylate. J Neuroradiol 2001;28:147–65.
. Hademenos GJ, Massoud TF. Risk of intracranial arteriovenous malformation rupture due to venous drainage impairment. A theoretical analysis. Stroke 1996;27:1072–83.