Clinical Trial/Experimental Study (CONSORT Compliant)
Reports of randomized trials must conform to the revised CONSORT guidelines and should be submitted with their protocols and a completed CONSORT checklist. All reports of clinical trials must include a summary of previous research findings and explain how the submitted trial affects this summary of previous findings. Cluster randomized trials should be reported according to extended CONSORT guidelines. Randomized trials reporting harms must be described according to extended CONSORT guidelines. All reports of randomized trials should include a section entitled "Randomization and masking" within the methods section. For information regarding CONSORT guidelines, please visit
Observational Study (STROBE Compliant)*
Observational research comprises several study designs and many topic areas. The STROBE statement should be used when reporting such research. The STROBE recommendations apply to the three main analytical designs used in observational research: cohort, case-control, and cross-sectional studies. The STROBE statement consists of a 22-item checklist. For information regarding STROBE guidelines, please visit
*Please note that
Medicine® uses a customized version of the STROBE checklist, available only at http://www.editorialmanager.com/md in the "Files & Resources" section of the home page.
Systematic Review and Meta-Analysis (PRISMA Compliant)
Systematic reviews and meta-analyses must be reported according to PRISMA guidelines, an evidence-based minimum set of items created to help authors improve the reporting of systematic reviews and meta-analyses. The PRISMA Statement consists of a 27-item checklist and a four-phase flow diagram. For information regarding PRISMA guidelines, please visit
Meta-Analysis of Observational Studies in Epidemiology (MOOSE Compliant)Systematic reviews and meta-analyses of observational studies in epidemiology should be reported according to MOOSE guidelines. For more information regarding MOOSE guidelines, please visit
Diagnostic Accuracy Study (STARD Compliant)
Investigators reporting studies of diagnostic accuracy should adhere to the STARD statement, part of the STARD initiative to improve the accuracy and completeness of reporting of studies of diagnostic accuracy, to allow readers to assess the potential for bias in a study (internal validity) and to evaluate a study's generalizability (external validity). The STARD statement consists of a 25-item checklist and recommends the use of a flow diagram to describe the design of the study and the flow of patients. For information regarding STARD guidelines, please visit
Quality Improvement Study (SQUIRE Compliant)*
The SQUIRE statement helps authors write excellent, usable articles about quality improvement in health care so that findings may be easily discovered and widely disseminated. The SQUIRE statement consists of a 19-item checklist. The SQUIRE guidelines are not exclusive of other guidelines. For example, an improvement project or effectiveness study that used a randomized controlled trial design should consider using both the CONSORT and the SQUIRE guidelines. In these cases, both checklists should be uploaded as a single document. For more information regarding SQUIRE guidelines, please visit
*Please note that
Medicine® uses a customized version of the SQUIRE checklist, available only at http://www.editorialmanager.com/md in the "Files & Resources" section of the home page.
Economic Evaluation Study (CHEERS Compliant)
Developed by the ISPOR Quality Improvement in Cost-Effectiveness Research Task Force , the CHEERS statement supports the quality, consistency, and transparency of health economic and outcomes research reporting in the biomedical literature. The CHEERS statement includes a 24-item checklist. For more information regarding CHEERS guidelines, please visit
Clinical Case Report (CARE Compliant)
The CARE guidelines provide a framework to support the need for completeness, transparency and data analysis in case reports and data from the point of care. The main tools of CARE are the CARE Statement, CARE checklist, and a Case Report Writing Template. These products offer a rationale and a standardized format for authors to prepare more complete and transparent case reports. For more information regarding CARE guidelines, please visit http://www.care-statement.org/.