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Research Article: Observational Study

Maternal anxiety in relation to growth failure and growth hormone treatment in children

Majewska, Katarzyna Anna PhDa; Stanisławska-Kubiak, Maia PhDb,∗; Wiecheć, Katarzyna MScb; Naskręcka, Monika PhDc; Kędzia, Andrzej PhDa; Mojs, Ewa PhDb

Editor(s): Tusconi., Massimo

Author Information
doi: 10.1097/MD.0000000000022147
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Abstract

1 Introduction

Health disorders in mothers and their children are subject to mutual influences arising from the nature of mother–child relationship. The development of this essential relation is initialized during pregnancy, and after childbirth the mothers of new-born babies undergo neurobiological changes supporting maternal attachment.[1–3] This process is influenced by multiple factors, including maternal psychological state, not only in terms of well-known depression, but also anxiety. Mothers with anxiety disorders are less engaged, less responsive, and demonstrate lower levels of sensitivity. These factors negatively affect mother–child relationship and increase the risk of disturbances in the child's development,[4,5] whereas long-term stress and negative emotional stimuli are the essential elements of the environment that may affect growth in children, causing temporary and reversible growth hormone deficiency.[6]

Short stature, when occurs as an isolated symptom, is not a life threatening condition. Children's intellectual development and motor abilities do not differ substantially from the average. Younger children in fact do not realize they are different. At the age of 8 to 9 years short children begin to be aware of their height in relation to others and at this point growth failure may influence negatively their psychosocial functioning.[7] Short stature is the essential symptom of growth hormone deficiency (GHD) in the developmental age. Treatment with recombinant human growth hormone (rhGH) allows children to grow, but it requires regular daily injections, multiple medical check-ups, and many years of continuous therapy to sustain sufficient growth. On the one hand, we have short-stature, but apart from that a generally healthy child, on the other—many years of regular injections and medical check-ups.[8]

Motherhood affects the mental state of women in numerous ways. The experience of being a mother may give some beneficial changes, as it is linked with an overall lower stress response and with improvements in certain aspects of memory,[9,10] nevertheless, motherhood is related to additional factors favoring depression, stress, and anxiety. Postpartum depression is a well-documented disturbance, but also mothers of older children may experience higher levels of stress and anxiety, especially if their children have health disorders.[11,12] There are reports regarding the influence of short stature and growth hormone therapy on quality of life, behavior, emotional status, and other aspects of psychosocial functioning in children.[13–18] Still, little is known about the maternal psychological functioning in this condition, which is quite surprising considering the nature of the mother–child relationship.

The aim of the present study was to analyze the complex interplay between short stature in children and the anxiety levels in their mothers. Could high anxiety trait in mothers be associated with growth failure in their children? Could anxiety represent a transient state of a mother whose child is affected by growth failure? What is the influence of growth hormone therapy in short children on the anxiety levels in their mothers?

2 Materials and methods

The study was based on a group of 101 mothers of children with growth failure: 75 boys and 26 girls aged 5 to 16 years. In this group, 70 children received a diagnosis of GHD and were treated with rhGH for a variable period of time; 31 children were undergoing the diagnostic process required to determine the short stature aetiology, without any treatment. Detailed group characteristics are presented in Table 1. Only mothers with one short-stature child were recruited. All mothers were evaluated during the medical check-ups of their children. The study excluded adoptive mothers, and those whose children had additional chronic or acute diseases that could affect test results.

Table 1
Table 1:
Clinical characteristics of analyzed group of children with short stature, and anxiety levels of their mothers.

Medical data collected for the purposes of the study included the child's gender, height and weight, chronological age, bone age delay (estimated as a difference between the bone and the chronological age), and growth hormone therapy duration. Based on these data, for all the children the height SDS (standard deviation score of child's height in relation to gender and age) and BMI SDS (standard deviation score of child's body mass index in relation to gender and age) were calculated in accordance with the guidelines.[19,20]

The Spielberger State-Trait Anxiety Inventory (STAI) was used to assess the anxiety levels in mothers.[21,22] It is a widely used, 40-item questionnaire that estimates both state (STAI-S) and trait anxiety (STAI-T). Anxiety as a state is interpreted as a transient condition, and anxiety as a trait is considered as a relatively constant feature of personality. The first part (questions 1–20) assesses anxiety reactions to the current situation, the level of anxiety at the time of the study. The second part (questions 21–40) evaluates the individual predisposition to experience anxious responses. The questionnaire rates all the responses on a four-point intensity scale ranging from 1 to 4. Subsequently the results are calculated into sten scores, defined by reference to a standard normal distribution, with a mean of 5.5 and a standard deviation of 2. Interpretation of the scale: 5 to 6 sten scores points at the average intensity of anxiety, below these values anxiety is rated as low, while above is rated as high. STAI has strong psychometrics. The reliability of Polish version was based on internal compliance and absolute stability assessment of both its subscales. Internal compliance calculated by Cronbach's alpha coefficient is 0.84 to 0.94.

Medical data and psychological questionnaires were collected and analyzed in years 2015 to 2019. Participation in the study was voluntary.

In the statistical analysis Kolmogorov–Smirnov test was used in evaluating the compatibility of the variables with the normal distribution. For quantitative variables compatible with the normal distribution Pearson correlations were calculated, while Spearman correlations for qualitative and non-normally distributed variables. Subsequently, the test of significance for a correlation coefficient was used to assess the relevance of interdependence for all correlations between the analyzed traits. Furthermore, a one-sided test of means with two groups and different variances was used (Student's t test). For the examined model, also ANOVA test for independent samples was performed followed by a post hoc NIR test. The statistical power analysis for the obtained sample size was 0.966. P value < .05 was prospectively determined to indicate significant differences. Statistical analysis was performed in Gretl 1.10.1.

The study has been carried out in accordance with the Code of Ethics of the World Medical Association. Its protocol was approved by the local Ethics Committee at Poznan University of Medical Sciences. All mothers gave informed consent.

3 Results

Anxiety as a trait was low in all the recruited mothers, and no statistically significant difference (P = .156) emerged in a subgroup analysis based on their children treatment status (i.e., lack of a diagnosis/treatment vs GHD under treatment). However, when considering anxiety as a state the overall sample presented medium anxiety levels and a statistically significant difference emerged between the two subgroups, with the mothers of children without a diagnosis or treatment presenting higher levels of anxiety (P = .001). Detailed results are presented in Table 1.

The results further suggest an inverse association between maternal state anxiety and the child's chronological age in the subgroup undergoing pharmacological treatment, with the mothers of younger children experiencing the highest levels of state anxiety; the association was lost when analyzing the subgroup with no diagnosis or treatment (Table 2). Furthermore, no correlation was observed between maternal state anxiety and the child's gender, bone age delay, height SDS or BMI-SDS.

Table 2
Table 2:
Correlations of anxiety levels in mothers with their children medical data.

Anxiety levels in mothers were also associated with the duration of rhGH treatment (Tables 2 and 3). Statistical analysis was performed for all mothers, and for this purpose the total sample was divided into four subgroups: mothers of not treated children, treated for a short period of time (up to 1 year), treated for a moderate period of time (from 1 to 4 years), and treated for a long period of time (above 4 years). Significant reduction of maternal state anxiety was observed at the first stage of the therapy, and then was further reduced in mothers of children treated for more than 4 years.

Table 3
Table 3:
Maternal anxiety in aspect of growth hormone treatment duration in children.

4 Discussion

The illness of a child, including short stature, or the need for ongoing growth hormone treatment, requires numerous adaptations in many aspects of the everyday life for the child and the family, which in turn demands mastering new psychological competencies. This includes expectations of parents towards their children's appearance, effects of the therapy, and a child's potential positive or negative reaction to the therapeutic process. Parents may be concerned about the necessity of long-term treatment, the method of growth hormone administration (injections), as well the potential side effects, but also often ask themselves questions about the future life of their children, the impact of the disease on education, daily life, contacts with peers. Parental distress may in turn generate problems with self-esteem in a child and impair developing skills related to the appropriate treatment.[23,24] What is important, effective therapy with growth hormone requires close cooperation of parents with attending physician, and their understanding of the treatment principles, as they are responsible for daily medicine administration at home, in strict accordance with medical recommendations.[25–27] In conclusion, parental attitude and emotional state may, in a favorable or unfavorable manner influence the effectiveness of treatment.

The STAI, used in the present study to evaluate the level of anxiety in mothers, allows to distinguish between state and trait anxiety. State anxiety, as a transient condition, is characterized by high volatility under the influence of a wide variety of stressors. Trait anxiety, as a feature of personality, determines predisposition to initiate anxiety behavior during cognitive processes. Research studies indicate that people with high trait anxiety, compared to those with its low intensity, do not necessarily demonstrate permanently higher levels of state anxiety. They will however react with anxiety in situations highly threatening or perceived as stressful by them.[22]

Analyzing the issue of short stature in children, maternal state anxiety could be interpreted as a transient reaction, related to the diagnostic process and unclear health status of the child, resolving when the appropriate treatment is initiated and the child begins to grow. It could also be associated with a long-term and inconvenient process of treatment, but then the levels of state anxiety in mothers would not decrease during the therapy. Trait anxiety, as a relatively constant attribute of personality, should not be subject to substantial changes, but mothers with high basic levels of trait anxiety may be sensitive to any distress. Narrow field of interest and a tendency to interpret signals in a particular way may escalate anxiety as a state.

The results of the present study show high levels of state anxiety in mothers of short children without final diagnosis and treatment, significantly higher than in mothers of children diagnosed with GHD and treated with growth hormone. This means that unclear health status and uncertain medical prognosis regarding further growth is generally a much stronger stressor for mothers than the necessity for long-term treatment and regular injections.

Surprisingly—obtained results point at the low level of trait anxiety among all the analyzed mothers—lower than the average. Perhaps for mothers with low trait anxiety it is easier to deal with the problem of short stature in their children, and to seek a solution to this problem, which is a medical specialist advice. It is possible that mothers with higher levels of trait anxiety find it more difficult to solve the problem, and so they less frequently get proper medical care. It cannot also be excluded that mothers with a higher level of trait anxiety would avoid participating in a voluntary survey. Still, this result indicates that the occurrence of short stature in children is not related to high maternal trait anxiety.

Mothers of younger children present higher levels of state anxiety, which may result from the nature of mother–child relationship and a pronounced dependence of younger children on their mothers. However, in the group of children treated with growth hormone, the observed reduction of state anxiety in mothers associated with the increase in child's age may be related to the duration of treatment and the gradual improvement of growth, because in the group of untreated children its level remains consistently high and did not change with advancing age.

Analysis of maternal anxiety in relation to height SDS revealed no statistically significant dependency on the degree to which children's height differs from the average in a population of appropriate age and gender. A similar analysis performed for BMI-SDS showed that the relative excess or deficiency of body weight in children have also no impact on the level of anxiety in mothers.

In turn, the rhGH treatment duration plays an important role in regulating maternal anxiety level. It seems like it is enough just to implement this therapy to reduce state anxiety, even before obtaining its visible effectiveness—the growth improvement. Anxiety decreased significantly in the first year of the medicine administration, despite struggling with the new situation, with regular injections and medical check-ups. A slight increase during the period from 1 to 4 years of the therapy could be a delayed result of the treatment inconveniences. The lowest level of state anxiety observed among mothers of children treated for more than 4 years may be further associated with improved growth, as a result of prolonged treatment.

Anxiety is the most common disease-associated reaction, and due to its vegetative and motivational nature, it affects the treatment process. The level of anxiety is subject to change depending on the individual situation, stage of treatment and other personality traits.[21,27] In the initial stage of the disease, moderate anxiety favors rising activity, determining plans, and taking actions. Thereafter, if the anxiety persists, it often leads to excessive concentration on health and overprotection, but it can also promote the mechanism of denial and non-compliance with medical recommendations and even sometimes the withdrawal from treatment.[8,23,28] That would be a substantial problem in mothers of children treated with growth hormone, since the efficacy of this therapy depends primarily on strict compliance with medical recommendations—regarding dosage, method of administration and the medication storage. In this group, however, the level of anxiety is average and low, so it should not affect the treatment course. In turn, state anxiety in mothers of not treated children is high, so it may have a negative impact on the diagnostic process and bring the risk of discontinuation of tests aimed to find the cause of short stature. In this group, it would be advisable to identify mothers with the highest level of anxiety and provide them with psychological support to reduce the risk of children dropping out of care.

Our study analyzed the present psychological condition of mothers, and while anxiety as a maternal personality trait should be relatively stable throughout the child's life, the maternal anxiety as a state was probably subject to multiple changes. For further research, it would be advisable to evaluate and analyze also other, apart from anxiety, personality traits of mothers. It would also be valuable to estimate maternal psychological condition in terms of substantial distress in the past, especially during the infancy of children being later diagnosed and treated due to short stature.

5 Conclusions

Growth failure in Polish children is not associated with high maternal anxiety as a personality trait. However, lack of diagnosis and lack of appropriate treatment in short children seem to generate high levels of anxiety as a transient state in their mothers—higher than the process of growth hormone treatment with its inconveniences. The mere commencement of the therapy causes a substantial reduction of state anxiety in mothers, and advancing duration of treatment causes its further decrease.

Mothers of short children undergoing diagnostic process could benefit from psychological support, but it seems to be unnecessary when their children are treated with growth hormone.

Author contributions

Conceptualization: Katarzyna A. Majewska, Maia Stanisławska-Kubiak.

Data curation: Katarzyna A. Majewska, Maia Stanisławska-Kubiak, Katarzyna Wiecheć, Monika Naskręcka.

Formal analysis: Katarzyna A. Majewska, Maia Stanisławska-Kubiak, Monika Naskręcka.

Investigation: Katarzyna A. Majewska, Maia Stanisławska-Kubiak, Katarzyna Wiecheć.

Methodology: Katarzyna A. Majewska, Maia Stanisławska-Kubiak.

Project administration: Katarzyna A. Majewska, Maia Stanisławska-Kubiak.

Resources: Andrzej Kędzia, Ewa Mojs.

Supervision: Andrzej Kędzia, Ewa Mojs.

Writing – original draft: Katarzyna A. Majewska, Maia Stanisławska-Kubiak.

Writing – review & editing: Andrzej Kędzia, Ewa Mojs, Monika Naskręcka.

References

[1]. Alhusen JL. A literature update on maternal-fetal attachment. J Obstet Gynecol Neonatal Nurs 2008;37:31528.
[2]. Kim P, Strathearn L, Swain JE. The maternal brain and its plasticity in humans. Horm Behav 2016;77:11323.
[3]. Pisoni C, Garofoli F, Tzialla C, et al. Risk and protective factors in maternal-fetal attachment development. Early Hum Dev 2014;90:456.
[4]. Nicol-Harper R, Harvey AG, Stein A. Interactions between mothers and infants: impact of maternal anxiety. Infant Behav Dev 2007;30:1617.
[5]. Stein A, Craske MG, Lehtonen A, et al. Maternal cognitions and mother-infant interaction in postnatal depression and generalized anxiety disorder. J Abnorm Psychol 2012;121:795809.
[6]. Stanhope R, Gohlke B. The aetiology of growth failure in psychosocial short stature. J Pediatr Endocrinol Metab 2003;16:3656.
[7]. Chaplin JE, Kriström B, Jonsson B, et al. When do short children realize they are short? Prepubertal short children's perception of height during 24 months of catch-up growth hormone treatment. Horm Res Paediatr 2012;77:2419.
[8]. van Dongen N, Kaptein A. Parents’ views on growth hormone treatment for their children: psychosocial issues. Patient Prefer Adherence 2012;6:54753.
[9]. Bridges RS. Long-term alterations in neural and endocrine processes induced by motherhood in mammals. Horm Behav 2016;77:193203.
[10]. Macbeth AH, Luine VN. Changes in anxiety and cognition due to reproductive experience: a review of data from rodent and human mothers. Neurosci Biobehav Rev 2010;34:45267.
[11]. Brummelte S, Galea LA. Postpartum depression: etiology, treatment and consequences for maternal care. Horm Behav 2016;77:15366.
[12]. Dipietro JA, Costigan KA, Sipsma HL. Continuity in self-report measures of maternal anxiety, stress, and depressive symptoms from pregnancy through two years postpartum. J Psychosom Obstet Gynaecol 2008;29:11524.
[13]. Bullinger M, Koltowska-Haggstrom M, Sandberg D, et al. Health-related quality of life of children and adolescents with growth hormone deficiency or idiopathic short stature. Part 2: available results and future directions. Horm Res 2009;72:7481.
[14]. Lee JM, Appugliese D, Coleman SM, et al. Short stature in population-based cohort: social, emotional, and behavioral functioning. Pediatrics 2009;124:90310.
[15]. Sandberg DE, Voss LD. The psychosocial consequences of short stature: a review of the evidence. Best Pract Res Clin Endocrinol Metab 2002;16:44963.
[16]. Sandberg DE, Bukowski WM, Fung CM, et al. Height and social adjustment: are extremes cause for concern and action? Pediatrics 2004;114:74450.
[17]. Voss LD, Mulligan J. Bullying In school: are short pupils at risk? Questionnaire study in a cohort. BMJ 2000;320:6123.
[18]. Wiren L, Johnannson G, Bengtsson B. A prospective Investigation of quality of life and psychological well-being after the discontinuation of GH treatment in adolescent patients who had GH deficiency during childhood. J Clin Endocrinol Metab 2001;86:34948.
[19]. Kułaga Z, Grajda A, Gurzkowska B, et al. Polish 2012 growth references for preschool children. Eur J Pediatr 2013;172:75361.
[20]. Kułaga Z, Litwin M, Tkaczyk M, et al. Polish 2010 growth references for school-aged children and adolescents. Eur J Pediatr 2011;170:599609.
[21]. Sosnowski T, Wrześniewski K. Polska adaptacja inwentarza STAI do badania stanu i cechy lęku. Przegląd Psychologiczny 1983;26:393412.
[22]. Spielberger CD. Spielberger CD, Sarason IG. Anxiety: state-trait process. Stress and Anxiety. Vol. 1. Washington: Hemisphere/Wiley; 1975. 11543.
[23]. Haverkamp F, Gasteyger C. A review of biopsychosocial strategies to prevent and overcome early-recognized poor adherence in growth hormone therapy of children. J Med Econ 2011;14:44857.
[24]. Naiki Y, Horikawa R, Tanaka T. Assessment of psychosocial status among short-stature children with and without growth hormone therapy and their parents. Clin Pediatr Endocrinol 2013;22:2532.
[25]. Cutfield WS, Derraik JG, Gunn AJ, et al. Non-compliance with growth hormone treatment in children is common and impairs linear growth. PLoS One 2011;6:e16223.
[26]. Pao M, Ballard ED, Raza H, et al. Pediatric psychosomatic medicine: an annotated bibliography. Psychosomatics 2007;48:195204.
[27]. Voss LD. Short normal stature and psychosocial disadvantage: a critical review of the literature. J Pediatr Endocrinol Metab 2001;14:70111.
[28]. Visser-van Balen H, Sinnema G, Geenen R. Growing up with idiopathic short stature: psychosocial development and hormone treatment; a critical review. Arch Dis Child 2005;91:4339.
Keywords:

anxiety; short stature; growth hormone therapy; mothers; children

Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.