Statement of Concern : Medicine

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Statement of Concern

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doi: 10.1097/MD.0000000000021299
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Medicine is publishing a statement of concern regarding two Medicine articles.

The journal was alerted to concerns alleging improper statistical analysis in published article “Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease”[1] which appeared in Volume 99, Issue 10 of Medicine. After investigation, it was found that the analysis performed was inappropriate and as a result, the data must be re-analyzed and corrected appropriately. It was also alleged that in published article “A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease”[2] appearing in Volume 98, Issue 12 of Medicine, between-group tests are reported using the final measure. However it does not seem to be correctly calculated. It was also determined through investigation that the ‘interaction effect’ of exercise on primary (and subsequent outcome measures) cannot be statistically interrogated in.[2]

Additionally, a concern was raised regarding potential duplication of results in[1] that were reported in[2] and “Effect of Moderate-Intensity Aerobic Exercise on Hepatic Fat Content and Visceral Lipids in Hepatic Patients with Diabesity: A Single-Blinded Randomised Controlled Trial”[3] which appeared in Volume 2020 of Evidence-Based Complementary and Alternative Medicine. After investigation, it appears duplication did not occur as[1] presents an experimental arm (MICT), although authors appear to have failed to include deviations to experimental arms in the clinical trial registration.

The original Letter to the Editor documenting the concerns has been published on our Author Correspondence blog. Authors and their institutions have been contacted to address the concerns, re-analyze data, and ensure all clinical trial registration information is accurate.

References

[1]. Abdelbasset WK, Tantawy SA, Kamel DM. Effects of high-intensity interval and moderate-intensity continuous aerobic exercise on diabetic obese patients with nonalcoholic fatty liver disease: A comparative randomized controlled trial. Medicine. 2020; 99:e19471.
[2]. Abdelbasset WK, Tantawy SA, Kamel DM. A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease. Medicine. 2019 98:e14918.
[3]. Abdelbasset WK, Elsayed SH, Nambi G. Effect of Moderate-Intensity Aerobic Exercise on Hepatic Fat Content and Visceral Lipids in Hepatic Patients with Diabesity: A Single-Blinded Randomised Controlled Trial. Evid Based Complement Alternat Med. 2020; 1923575.
Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.