After the spread of the coronavirus disease 2019 (COVID-19) globally, a patient was first reported, as a result, a community transmission has been rapidly evolved in Thailand. As of April 26, 2020, the COVID-19 caused 51 deaths of the 2922 confirmed cases, and 101 health care workers have been infected in both central and regional parts of Thailand. Based on the information concerning the confirmed cases, upgraded quarantine and physical distancing strategy, strict infection measures, and government's strict lockdown have been abided to confront the spread of the COVID-19 in Thailand.
Facing this large-scale infectious public health event, the ever-increasing number of confirmed and suspected cases, heavy workloads, negative emotions, depletion of personal protection equipment, lack of specific drugs, and feelings of being inadequately supported may all contribute the mental burden of health care workers. Meanwhile, confirmed and suspected cases of COVID-19 may experience fear of disease progression and the transmission to their family and friends. Concerns about the mental health and psychosocial problems among the general population are now arising owing to fear of contagion, perception of danger, widespread media coverage, financial problems, and unemployed related to the COVID-19 outbreak.
Taken together, the infectious disease outbreaks, including the COVID-19 pandemic, can lead to the feeling of uncertainty, anxiety, and fear, and stigmatization in both health care workers and the general population who are under quarantine or at home. As such, it was postulated that the quarantined individuals, health care workers, as well as the general population are at risk of developing psychological distress and other mental health problems. To provide more advanced mental health care at the time of the pandemic, it is necessary to understand the mental health status and psychosocial problems of health care workers and the general population.
To our knowledge, however, little is known about how the COVID-19 pandemic may affect the mental health status and psychosocial problems of the health care workers and the general population in Thailand. Therefore, we will conduct a repeated cross-sectional study to understand the short- and long-term responses to the COVID-19 outbreak, examine the prevalence of mental health status, psychosocial related to the COVID-19 pandemic, and identify associated factors among a national sample of health care workers and the general population in Thailand.
2 Objectives of the survey
- To examine the prevalence of mental health and psychosocial problems among health care workers and the general population in Thailand during the COVID-19 pandemic.
- To document the changes over a 1-year follow-up of psychological response to a national infectious public health event.
- To identify early and late predictors of mental health status in response to the COVID-19 outbreak.
- To establish the prevalence of mental health status among health care workers and the general population worldwide during the COVID-19 pandemic.
3.1 Study design and time-period
The Health Outcomes and Mental Health Care Evaluation Survey: Under the Pandemic Situation of COVID-19 (HOME-COVID-19) is a repeated cross-sectional study, an open online voluntary national-based survey conducted during the wave I (April 21, 2020 to May 4, 2020) follow-up in the wave II (August 3, 2020 to August 16, 2020), wave III (November 15, 2020 to November 28, 2020), and wave IV—a 1-year follow-up survey (closed out: April 21, 2021 to May 4, 2021).
3.2 Study population
The survey will use a convenient sampling and snowball strategies, and any health care workers (clinicians, nurses, and allied health staff [dentists, pharmacists, psychologists, occupational therapists, physiotherapists, case managers, and medical social workers]) working at the hospital and the general population in Thailand will be eligible for the online survey. The inclusion and exclusion criteria required for eligible participants are provided in Table 1.
3.3 Online survey conduct
With respect to the physical distancing strategy and minimize face-to-face interaction, we developed an online questionnaire via the SurveyMonkey (https://www.surveymonkey.com) that limits 1-time participation per unique internet protocol (IP) address. The researcher team will provide the relevant link or the Quick Response code (QR code) to all potential participants. For healthcare workers, all staff working at the hospital will be invited to participate in the online survey via the personal contact and healthcare community social media networks (email, LINE, Group of Messenger, Healthcare Professional Association) in Thailand. A convenience and snowball sampling strategy will be applied to recruit the general population through various social media networks including public websites, Facebook, LINE, Twitter, and Instagram. No reimbursement, other gifts, or payments will be offered for completing the questionnaire.
3.4 Study instrument and questionnaire design process
The general population will complete a set of questionnaires, about participant characteristics and specific tool regarding the mental health and psychosocial question. Also, health care workers will complete a separate set of questions. The survey questionnaire, written in Thai, comprised 13 main components. There are different types of questions in the questionnaire including (yes/no) questions, the Likert scale, multiple-choice questions, and open-ended questions.
The questionnaire will be carefully revised by a panel of health care professionals that include 3 epidemiologists, 2 psychiatrists, 1 social scientist, and 2 hospital directors. The questionnaire will be further validated by a pilot survey of 30 health care professionals and 30 general populations. This validation process is used to measure the time needed to complete the questionnaire and assure that all the questions and sections of the questionnaire are phrased clearly and appropriately for comprehension.
Baseline sociodemographic characteristics include age, sex, educational level, marital status, religion, occupation/profession status, the region of residence/hospital, living status, number of a household family member, monthly income, job/income loss related to COVID-19 outbreak, financial problems, reimbursement schemes, comorbidities, media exposure, working from home information, quarantine/isolation information, willingness to quarantine/work during COVID-19 outbreak, global rating scale on the degree of fear to COVID-19, self-rated level of preparedness, and resilience capability against the COVID-19 outbreak. For health care workers, a constructed questionnaire is carried out using the established framework of hospital disaster resilience through existing literature[4,5] and consultation with experts. These included the availability and adequacy of personal protective equipment and detailed information on hospital-level or capability related to COVID-19 outbreak and management.
A set of measurement tools for mental health and psychosocial problems for each subcohort are described in Table 2. We will focus on symptoms of depression, anxiety, stress, resilient copings, neuroticism, perceived social support, well-being, somatic symptoms, insomnia, burnout (for health care workers), and public stigma toward COVID-19 infection (for the general population), using a Thai version of validated measurement tools or our team development version tools. Detail of participants’ timeline and assessment for each wave of the survey is illustrated in Table 3.
4 Statistical analysis plan
4.1 Sample size and power calculation
The target sample size of participants was estimated based on the previous studies among health care workers or general population under the COVID-19 outbreak: prevalence of mental health problems (depression, anxiety, stress, and psychological distress) with a range of 5.2% to 71.5%[16–25] and 3.3% to 75.5%[20,22,23,26–31] for health care workers and the general population, respectively. To compensate for a design effect of 2.0 and a completed responses rate of 60%, a target of at least 1182 health care workers and 1310 general populations is required to complete the online survey for each wave of the survey to ensure a power of 80% and a 0.05 type I error. However, there will be no restriction on the number of participants in this online survey.
4.2 Data management
The collected data will be organized by the Google Form and collected in an Excel spreadsheet. The online survey will be completely anonymous and uploaded to a Google Drive encrypted by a password. Only the management team can access all data. Data entered into the Google Form will be quality-checked by a researcher to ensure accuracy. All steps involved in the approach to data management will be independently conducted by 2 data administrators from the Pharmacoepidemiology and Statistics Research Center (PESRC).
4.3 Statistical analysis
Data synthesis will be conducted separately for health care workers and the general population. Descriptive data statistic will be summarized as number (percentage) or mean ± standard deviation, or median with an interquartile range as suitable. Differences in responses with respect to baseline characteristics will be assessed using Fisher exact test and unpaired t test or Wilcoxon rank-sum test for categorical and continuous data, respectively.
For all estimates of prevalence, we will weight data for all wave surveys (wave I, II, III, and IV) analyses under the complex design of the survey—weighting adjusted for noncompleted responses survey and national rates of unemployment at the time of each survey. Population control totals for age by sex and region, and the rate of internet use will be obtained from the National Statistic Office, Ministry of Information and Communication Technology, Thailand. The estimates of the prevalence of mental health status will be calculated and reported along with the 95% confidence intervals (CIs). Subgroup analyses stratified by key characteristics (eg, age, sex, region, working position [frontline or nonfrontline], hospital type, and region of residence) will also be done to analyze the proportion differences.
Moreover, an online wave II, III, and a 1-year follow-up survey will be compared to assess the long-term responses and resilience capability on the prevalence of mental health status among health care workers and the general population. Nonoverlapping 95% CIs are indicating statistical differences in the prevalence between the survey wave or subgroups, with the P values that are based on the trend tests. The absolute change in prevalence will be calculated with the formula: Δ = (1/duration between survey) × (plast – pinitial), with variance estimated as (var [plast] + var [pinitial])/(duration between survey), where plast and pinitial, stand for the last prevalence and initial prevalence, respectively. Trend analysis will be performed to identify the effect of overtime across the study time frame.
For the survey—wave I, the crude association between participant characteristics will be assessed through the univariable logistic regression models to identify the candidate risk factors of early mental health problems. Subsequently, risk factors with a P value <.100 were then included in the multivariate logistic regression analysis with the stepwise backward method. The final model was also determined for multicollinearity by investigation of the variance inflation factors of the risk factors within the multivariable model. The effect estimates of the final risk factors model for mental health problems will be expressed as odds ratios (ORs) with corresponding 95% CIs.
For the repeated cross-sectional survey, we will combine the data from the wave I to wave IV survey to analyze changes in the mental health status. We will perform multilevel logistic regression models with random intercepts to explore associations with individual-level and region-level/hospital-level predictors. The survey wave will be analyzed as a level 1 variable with a fixed effect to distinguish between study survey waves across the study time frame.
To improve the generalizability of study findings, we also plan to perform an ancillary systematic review and meta-analysis by incorporating data from our findings to all available evidence regarding the mental health and psychosocial problems among health care workers and the general population. The prespecified protocol for systematic review has been registered in the International Prospective Register of Systematic Reviews (PROSPERO: registration number, CRD42020177120). Globally, the mental health problems attributable to the general population during the COVID-19 pandemic will be estimated by multiply the pooled prevalence of our findings against the United Nations’, world population report.
Missing data or noncompleted responses will be excluded from the primary analyses. However, a multiple imputation method will be performed in the sensitivity analysis. All analyses will be performed using Stata software version 14.0 (StataCorp, LP) and Microsoft Excel version 2016. They will be 2-tailed and P value <0.05 will be considered statistically significant.
5 Ethics and dissemination
5.1 Ethics approval and consent to participate
Ethics approval has been granted for the study by the Committee of Research Ethics in Faculty of Public Health (ET010/2020) and Faculty of Pharmacy (23/2563), Chiang Mai University. This study protocol will be performed according to the Declaration of Helsinki. All protocol amendments will be submitted to the ethics committees for approval. The protocol version 2–2020, dated April 23, 2020 was used to prepare this manuscript.
All respondents are required to fill a written informed consent (embedded on the first page of the survey questionnaire) before participating in this survey. If the participant answers “Yes” to the first question of the form, they automatically agree to participate and will be the survey. By using the skip-logic survey method, users who disagree with the informed consent question will be conducted to the end of the survey. No respondent is forced to participate in the survey and their participant is based on their agreement that can be withdrawn at any time. All participants have the right to leave a specific question unanswered or withdraw from the survey any time if they feel uncomfortable answering any question. Moreover, no one even the research team will know individual answers to this questionnaire.
5.2 Autonomy and confidentiality
All participants have the right to leave a specific question unanswered or withdraw from the survey any time if they feel uncomfortable answering any question. Moreover, no one even the research team will know individual answers to this questionnaire. All data are anonymous and are not able to identify the participants. The collected electronic data will remain confidential and only authorized team members will have access to it. Furthermore, data will be completely encrypted and coded for use mainly in statistical analysis using computer software.
5.3 Dissemination of results
Our findings will be disseminated through public, scientific, and professional meetings, and publications in peer-reviewed journals. Summary results in the lay written manner will also be available to the public. The investigators commit to reporting the results in line with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies and Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).
Since the end of December 2019, the Chinese city of Wuhan has reported novel pneumonia caused by coronavirus disease 2019 (COVID-19) pneumonia outbreak (previously referred to as “Wuhan pneumonia” or 2019 Novel Coronavirus [2019-nCoV]). Due to potentially serious health outcomes, from January 23, 2020, Wuhan and other regions in mainland China have adopted strict quarantine measures to control the widespread of the COVID-19 outbreak. Subsequently, person-to-person transmission has been recorded outside mainland China, which is spreading domestically and internationally. On January 30, 2020, the World Health Organization (WHO) declared the global COVID-19 outbreak a public health emergency concern, consequently characterizes as a pandemic on March 11, 2020. As of April 26, 2020—situation report-97—a total of 2,810,325 confirmed cases with 193,825 confirmed deaths have been documented globally.
The negative emotion and psychosocial distress may occur among frontline health care workers who have directly involved with the COVID-19 patients, which characterized by unintentional missing, trigger events considered into the mistake, and delay treatment owing to the communication failure. A cross-sectional study of 1257 health care workers who treated patients exposed to COVID-19 in multiple regions of china (including Wuhan) by Lai et al, 2020, revealed that participants reported symptoms of depression 50.4%, anxiety 44.6%, insomnia 34.0%, and distress 71.5%. Not surprisingly, frontline health care workers were associated with a higher risk of depression (OR, 1.52; 95% CI, 1.11–2.09; P = .010), anxiety (OR, 1.57; 95% CI, 1.22–2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92–4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25–2.04; P < .001).
The affected people were also subject to societal rejection, discrimination, and stigmatization. Evidence suggests that the psychological impact of quarantine is wide-ranging, substantial, and can be long-lasting, including post-traumatic stress symptoms, confusion, and anger. A wide range of psychological and nonpsychological outcomes was reported and has negative consequences for segregated patients among isolation hospitalized patients who are infectious to contain the risk of infection. Moreover, loneliness, anger, frustration, and boredom could be experienced by individuals in the quarantine period. Interestingly, the previous report among the exposed individuals in the quarantine period with the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Korea found that 7.6% and 16.6% expressed anxiety and feelings of anger symptoms, respectively.
To our knowledge, this is the first prospective, a repeated cross-sectional study among health care workers and the general population in Thailand. Given the limited evidence at a national level, our study will comprise an early- and long-term mental health status and responses to the COVID-19 outbreak in Thai health care and the general population. Our findings will also plan to perform an ancillary analysis by incorporating all available evidence to further systematic review and meta-analysis. However, as this study leverages online survey data, thereby, responses rates and incomplete information in some questionnaires may limit our findings.
This prospective repeated cross-sectional study, the national-based online survey will report the prevalence of mental health and psychosocial problems among health care workers and the general population in Thailand during the time of the COVID-19 pandemic. Findings from our study can aid health care professionals, public health officials, and public society by quantifying and identify factors that may accelerate or mitigate the negative impact of the COVID-19. This information can inform the design of strategies for public policy and cope with mental health and psychosocial life events. Our findings will disseminate in the forms of public and scientific meetings along with the peer-reviewed publication.
Conceptualization: Surapon Nochaiwong, Chidchanok Ruengorn, Nahathai Wongpakaran, Tinakon Wongpakaran
Data curation: Ratanaporn Awiphan, Yongyuth Ruanta, Waraporn Boonchieng, Sirisak Nanta, Woravut Kowatcharakul, Wanida Pumpaisalchai, Penkarn Kanjanarat, Pajaree Mongkhon
Formal analysis: Surapon Nochaiwong, Chidchanok Ruengorn, Nahathai Wongpakaran, Tinakon Wongpakaran
Funding acquisition: Surapon Nochaiwong
Investigation: Surapon Nochaiwong, Chidchanok Ruengorn, Nahathai Wongpakaran, Tinakon Wongpakaran
Methodology: Surapon Nochaiwong, Chidchanok Ruengorn, Kednapa Thavorn, Brian Hutton
Supervision: Surapon Nochaiwong
Writing – original draft: Surapon Nochaiwong,
Writing – review & editing: all authors
. World Health Organization. COVID-19 - WHO Thailand Situation Reports. 2020; available at: https://www.who.int/thailand/emergencies/novel-coronavirus-2019/situation-reports
. Accessed April 27, 2020.
. Chen Q, Liang M, Li Y, et al. Mental health care for medical staff in China during the COVID-19 outbreak. Lancet Psychiatry 2020;7:e15–6.
. Pfefferbaum B, North CS. Mental health and the Covid-19 pandemic. N Engl J Med 2020;doi: 10.1056/NEJMp2008017. [Epub ahead of print].
. Fallah-Aliabadi S, Ostadtaghizadeh A, Ardalan A, et al. Towards developing a model for the evaluation of hospital disaster resilience: a systematic review. BMC Health Serv Res 2020;20:64.
. Zhong S, Clark M, Hou XY, et al. Development of hospital disaster resilience: conceptual framework and potential measurement. Emerg Med J 2014;31:930–8.
. Lotrakul M, Sumrithe S, Saipanish R. Reliability and validity of the Thai version of the PHQ-9. BMC Psychiatry 2008;8:46.
. Spitzer RL, Kroenke K, Williams JB, et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006;166:1092–7.
. Wongpakaran N, Wongpakaran T. The Thai version of the PSS-10: an investigation of its psychometric properties. Biopsychosoc Med 2010;4:6.
. Sinclair VG, Wallston KA. The development and psychometric evaluation of the Brief Resilient Coping Scale. Assessment 2004;11:94–101.
. Banjongrewadee M, Wongpakaran N, Wongpakaran T, et al. The role of perceived stress and cognitive function on the relationship between neuroticism and depression among the elderly: a structural equation model approach. BMC Psychiatry 2020;20:25.
. Wongpakaran N, Wongpakaran T. A revised Thai multi-dimensional scale of perceived social support. Span J Psychol 2012;15:1503–9.
. Saipanish R, Lotrakul M, Sumrithe S. Reliability and validity of the Thai version of the WHO-Five Well-Being Index in primary care patients. Psychiatry Clin Neurosci 2009;63:141–6.
. Gierk B, Kohlmann S, Kroenke K, et al. The somatic symptom scale-8 (SSS-8): a brief measure of somatic symptom burden. JAMA Intern Med 2014;174:399–407.
. Morin CM, Belleville G, Belanger L, et al. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 2011;34:601–8.
. Maslach C, Jackson SE. The measurement of experienced burnout. J Occup Behav 1981;2:99–113.
. Lai J, Ma S, Wang Y, et al. Factors associated with mental health outcomes among health care workers exposed to Coronavirus Disease 2019. JAMA Netw Open 2020;3:e203976.
. Wang C, Pan R, Wan X, et al. Immediate psychological responses and associated factors during the initial stage of the 2019 Coronavirus Disease (COVID-19) epidemic among the general population in China. Int J Environ Res Public Health 2020;17:1729.
. Huang JZ, Han MF, Luo TD, et al. Mental health survey of 230 medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020;38:E001.
. Chew NWS, Lee GKH, Tan BYQ, et al. A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak. Brain Behav Immun 2020;Apr 21. pii: S0889-1591(20)30523-7. doi: 10.1016/j.bbi.2020.04.049. [Epub ahead of print].
. Huang Y, Zhao N. Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey. Psychiatry Res 2020;288:112954.
. Zhang WR, Wang K, Yin L, et al. Mental health and psychosocial problems
of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020;1–9. doi: 10.1159/000507639. [Epub ahead of print].
. Gao J, Zheng P, Jia Y, et al. Mental health problems and social media exposure during COVID-19 outbreak. PLoS One 2020;15:e0231924.
. Liu N, Zhang F, Wei C, et al. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Psychiatry Res 2020;287:112921.
. Lu W, Wang H, Lin Y, et al. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020;288:112936.
. Xu J, Xu QH, Wang CM, et al. Psychological status of surgical staff during the COVID-19 outbreak. Psychiatry Res 2020;288:112955.
. Qiu J, Shen B, Zhao M, et al. A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations. Gen Psychiatr 2020;33:e100213.
. Lei L, Huang X, Zhang S, et al. Comparison of prevalence and associated factors of anxiety and depression among people affected by versus people unaffected by quarantine during the COVID-19 epidemic in Southwestern China. Med Sci Monit 2020;26:e924609.
. Zhang Y, Ma ZF. Impact of the COVID-19 pandemic on mental health and quality of life among local residents in Liaoning Province, China: a cross-sectional study. Int J Environ Res Public Health 2020;17:2381.
. Tan W, Hao F, McIntyre RS, et al. Is returning to work during the COVID-19 pandemic stressful? A study on immediate mental health status and psychoneuroimmunity prevention measures of Chinese workforce. Brain Behav Immun 2020;Apr 23. pii: S0889-1591(20)30603-6. doi: 10.1016/j.bbi.2020.04.055. [Epub ahead of print].
. Lee SA, Jobe MC, Mathis AA. Mental health characteristics associated with dysfunctional coronavirus anxiety. Psychol Med 2020;1–2. doi: 10.1017/S003329172000121X. [Epub ahead of print].
. Cao W, Fang Z, Hou G, et al. The psychological impact of the COVID-19 epidemic on college students in China. Psychiatry Res 2020;287:112934.
. von Elm E, Altman DG, Egger M, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 2007;335:806–8.
. Eysenbach G. Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). J Med Internet Res 2004;6:e34.
. Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol 2020;92:401–2.
. World Health Organization. Coronavirus disease (COVID-19) Pandemic. 2020; Available at:https://www.who.int/emergencies/diseases/novel-coronavirus-2019
. Accessed April 27, 2020.
. Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020;395:912–20.
. Purssell E, Gould D, Chudleigh J. Impact of isolation on hospitalised patients who are infectious: systematic review with meta-analysis. BMJ Open 2020;10:e030371.
. Jeong H, Yim HW, Song YJ, et al. Mental health status of people isolated due to Middle East Respiratory Syndrome. Epidemiol Health 2016;38:e2016048.