Conventional computerized tomography (CT) examination can differentiate renal cortical tumor from urothelial carcinoma on the basis of the highly contrast-enhanced vessels in renal cortical tumors. However, the capillary distribution of renal cell carcinoma (RCC) has been under-investigated. Here, we present a micro-CT image of tumor tissue in a patient with RCC.
The patient was a 72-year-old woman with a past history of diabetes mellitus and hypertension. She did not have tumor-related symptoms.
The tumor was diagnosed using abdominal CT during her yearly routine health check. After radical nephrectomy, the tumor was subjected to pathological examination and micro-CT imaging. Pathological analysis confirmed a clear cell renal carcinoma. The capillary distribution of the tumor was significantly lesser than that of the normal cortex on micro-CT image.
Microvessels of RCC can be detected by micro-CT. We also found that the distribution of microvessels was uneven and lower than that in the normal cortex in this case. For a more general diagnosis, more micro-CT images of RCC tumors are needed.
aGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University
bDepartment of Dermatology, Chung Shan Medical University Hospital
cInstitute of Medicine, School of Medicine, Chung Shan Medical University
dDepartments of Obstetrics and Gynecology, Urology, and Medical Research, China Medical University Hospital, Taichung
eDepartment of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung
fDepartment of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
Correspondence: Yung-Hsiang Chen, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan (e-mail: email@example.com); Wen-Chi Chen, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan (e-mail: firstname.lastname@example.org).
Abbreviations: CT = computerized tomography, OV = object volume, RCC = renal cell carcinoma, TV = total VOI volume of whole sample.
How to cite this article: Lin TC, Chen HY, Yang YR, Liu PL, Chen YH, Chen WC. Decreased capillary density in renal cell carcinoma. Medicine 2019;98:36(e16910).
The authors alone are responsible for the content and writing of the paper.
Informed written consent was obtained from the patient for publication of this case report and accompanying images.
This study is supported in part by China Medical University (CMU106-S-32) and Taiwan Ministry of Science and Technology (MOST 107-2314-B-039-036 and MOST 107-2320-B-039-034).
The authors have no conflicts of interest to disclose.
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Received December 17, 2018
Received in revised form June 24, 2019
Accepted July 29, 2019
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