Spearman correlation coefficient analysis indicated negative correlations between PRRX1+ expression and VM (r = −0.333, P < .001) and CIP2A (r = −0.513, P < .001), though expression of CIP2A was positively associated with VM development (r = 0.349, P < .001) (Table 5).
CCRCC represents the most aggressive subtype of kidney cancer and poses a serious threat to human health. However, the clinical prognosis of CCRCC is influenced by progression, covering a complex network of gene interactions. As biomarkers for early detection and follow-up of the disease are not currently available, it is necessary to investigate the pathogenic mechanism of the molecular field of renal malignancy and the comprehensive utilization of biological markers for clinical diagnosis and treatment.
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