Effects of yoga on patients with chronic nonspecific neck pain: A PRISMA systematic review and meta-analysis : Medicine

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Research Article: Systematic Review and Meta-Analysis

Effects of yoga on patients with chronic nonspecific neck pain

A PRISMA systematic review and meta-analysis

Li, Yunxia MSc, RNa,b; Li, Siyuan BSc; Jiang, Jieqiong BS, RNd; Yuan, Sue PhD, RNa,b,∗

Editor(s): Tusconi., Massimo

Author Information
doi: 10.1097/MD.0000000000014649
  • Open


1 Introduction

Chronic nonspecific neck pain (CNNP) is a widespread public health problem in the modern world,[1] with a reported prevalence of 50% lifetime prevalence[2] and more and more frequent in adolescence.[3] CNNP is considered as persistent neck pain or severe discomfort in the neck for over 3 months,[4] which is caused by poor posture and mechanical and degenerative changes, excluding pain from neck cancer, infections fasciitis, or other areas of the body.[5] The 2018 Burden of Disease Report reported that CNNP was the sixth leading cause of disability in the United States of America in 2016,[6] and contributes to higher costs due to loss of productivity, disability, and increased absenteeism from work, resulting in $77.2 billion in annual medical expenses.[7]

Treatment methods for this chronic health condition are mainly drugs, surgery, and conservative therapies including exercise and acupuncture. There are more specific studies on tuina, acupuncture, and manipulation treatments, but the best conservative method is yet to be determined. In recent years, yoga has been recommended as a complementary and integrative medicine therapy for alleviation of various types of pain, including neck-related pain.[8–12]

Rooted in India, yoga has been populated in worldwide, combining physical postures (asana), breathing techniques (pranayama), and meditation (dyana)[13] to promote physical and mental well-being. A variety of different yoga styles have emerged that put varying levels of focus on physical and mental practices.[14] Yoga styles, such as Iyengar yoga and Ashtanga yoga, strongly focus on physical postures, while Kriya yoga, rely on meditation or breathing techniques.[15] In clinical research, all styles seem to be more or less equally effective.[16]

At present, there are a lot of studies have evaluated the efficacy of yoga for neck pain. Whereas the results of most studies are inconsistent.[17–26] So conducting a meta-analysis to explore the synthetical effects seems to be necessary. Only one meta-analysis[15] was found in databases up to now, which concluded that yoga has short-term effects on chronic neck pain, which only searched English-language databases and included 3 eligible studies, resulting in a relatively limited overall sample size. Therefore, the aim of this study was to systematically review published trails, and try to conduct a meta-analysis through a multiple literature search, which may including a larger sample size to investigate the potential effects of yoga on patients with CNNP if there were sufficient studies.

2 Methods

Details of the protocol for this systematic review and meta-analysis was registered on PROSPERO and can be accessed at www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42018108992. This study was conducted according to the PRISMA statement.[27]

2.1 Ethics statement

As all analyses were based on previously published studies, no ethical approval or patient consent was required.

2.2 Literature search strategies

To identify eligible studies, multiple search strategies, of electronic databases were conducted from their inception to January 2019. English databases including PubMed, Medline, Cochrane Library, Embase, Scopus, the Cochrane Central Register of Controlled Trials, and IndMed. Chinese databases including China National Knowledge Infrastructure (CNKI), WanFang Database, and VIP Information. We also conducted a manual search of key journals: Journal of Yoga & Physical Therapy established by USA, Europe, and Asia, as well as International Journal of Yoga established by India. Various combinations of Medical Subject Headings (MeSH) and non-MeSH terms were used: “neck pain” OR “chronic neck pain” OR “chronic nonspecific neck pain” OR “neck syndrome” OR “Myofascial Pain Syndrome of neck,” AND “yoga” OR “yog” OR “yogic mind sound resonance technique (MSRT)” OR “meditation.” Neck pain was defined as cervical spondylosis in Chinese, the same terms in Chinese databases were searched as well. Additionally, reference lists of identified original articles or reviews were also manually searched. We searched the literature without restriction to language and region. Studies were only eligible if they were published as a full article. The main search was screened independently by 2 review authors, and disagreements were resolved by a third author through discussion.

2.3 Criteria for study inclusion and exclusion

Randomized controlled trials (RCTs) and quasi-randomized controlled trials (q-RCTs) that examined the clinical outcomes of yoga intervention in adults with CNNP compared with those of other therapies except yoga (e.g., exercise, pilates, usual care, et al) were included. CNNP may include some people with a traumatic basis for their symptoms, but does not include people for whom pain is specifically stated to have followed sudden acceleration–deceleration injuries to the neck (whiplash).[28] Yoga intervention was required to include any types of yoga, no matter of physical postures, breathing techniques, meditation, or combination one or more of them. Studies on multimodal interventions that include yoga among others were excluded, and studies which reported the data that could not provide or change to the quantitative data such as mean (M), standard deviation (SD), and 95% confidence interval (95% CI) were also excluded.

2.4 Methods of study selection and data extraction

Searches on the aforementioned databases were conducted independently by 2 reviewers. Duplications were removed first by using a document manager (Endnote), and then the titles and abstracts of the obtained articles were scanned. If these initially satisfied the selection criteria, the full articles were reviewed to identified the potential studies. Information from the selected studies were independently extracted by 2 reviewers by using a data extraction form, including first author, publication year, region, design, sample size, age of study participants, comparison, program length, main outcomes and measurements, measure time, and author conclusion. Any disagreements were discussed with a third reviewer and resolved by consensus.

2.5 Quality assessment

The risk of bias of included studies was assessed by using an assessment tool, the “Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0” (updated in 2011 by the Cochrane Organization)[29] by 2 reviewers subjectively. The assessment tool covers 7 domains: random sequence generation (selection bias), allocation concealment (selection bias), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), selective reporting (reporting bias), and other biases. Bias were assessed as “low risk,” “high risk,” or “unclear risk.” Discrepancies were resolved through discussion and settled by a third reviewer.

2.6 Outcome measures

The primary outcomes of this study were the intensity of neck pain and disability associated with the neck, because these 2 parameters were the most common indicators of clinical outcomes in neck pain. The secondary outcomes were cervical range of motion (CROM), quality of life (QoL), and emotional state, which were also considered important for recovery of CNNP.

2.7 Statistical analyses

The statistical analyses software, Revman 5.3, was used to conduct this meta-analysis. Differences in M, SD, sample size, with 95% CI were measured to compare the yoga group with control group to investigate the changes in neck pain intensity, disability, CROM, QoL, and emotional states. Statistical heterogeneity between studies was tested using I2 statistics, which presented the percentage of the total variability among the studies that was caused by heterogeneity rather than chance.[30] The percentages of I2 around 25%, 50%, and 75% indicate low, medium, and high heterogeneity, respectively.[29] The χ2 test was used to assess whether differences in results were compatible with chance alone, a P-value ≤.10 was considered to indicate significant heterogeneity. If P > .10 and I2 < 50%, statistical heterogeneity was perceived to be acceptable and a fixed effects model was used to conduct the meta-analysis; otherwise, if P≤.10 and I2≥50%, statistical heterogeneity was perceived to be relatively high and a random effects model was used to perform the meta-analysis. Subgroup analysis and sensitivity analysis were further conducted to explore the source of such heterogeneity. If P≥10 studies with the same outcome were included, a funnel plot was used to assess publication bias of the included studies.

3 Results

3.1 Study selection

A total of 347 studies were identified via a multiple search strategy of electronic databases. Of these 297 were excluded because of duplication, or because they did not meet our inclusion criteria after going through the titles and abstracts. After reading the full text of the remaining 50 studies, 10 studies[17–26] including 686 cases were included in the quantitative synthesis and meta-analysis (Fig. 1).

Figure 1:
Flow diagram of studies identified, included and excluded.

3.2 Characteristics of eligible studies

The basic characteristics of these 10 studies were represented in Table 1, including 2 q-RCT[19,21] and 8 RCT.[17–18,20,22–26] These articles were from Turkey,[17] India,[18,26] Korea,[19] Sweden,[20] United States,[21] Germany,[22,24,25] and China,[20] were published between 2010 and 2018, cover 686 patients, and sample sizes ranging from 38 to 159. All the studies involved yoga intervention, including both exercise-based and meditation-based, and the program length ranging from 10 days to 12 weeks. Almost all of the studies measured neck pain intensity and associated disability.

Table 1:
Characteristics of the included studies.

3.3 Quality assessment

Fig. 2A presents the quality of the each trials included in this review, and Fig. 2B summarizes the quality of all included studies. As shown in Fig. 2B, all 8 RCTs[17–18,20,22–26] mentioned the method of “random,” of which, 6[17,20,22,24–26] clarified how the allocation sequence was randomly generated. Only 4[17,20–24,25] described allocation concealment. Because the practitioners and the participants were directly involved in the treatment, it was impossible for them to be blinded to their allocation. Nevertheless some trails were designed to be unknown for patient allocation to the outcome assessors, there were 4[17,18,20,23] and 5[17,18,20,23,24] reported the “blinding of participants and personnel” and “blinding of outcome assessment,” respectively.

Figure 2:
(A) Risk of bias graph. (B) Risk of bias summary.

3.4 Primary outcomes

3.4.1 Neck pain intensity

Pooling the data from 10 studies[17–26] that assessed neck pain intensity showed there were significant difference between the yoga and control groups (total effect: SMD = −1.13, 95% CI [−1.60, −0.66], Z = 4.75, P < .00001). In subgroup analysis, there were also significant difference between the yoga and exercise group (subtotal effect: SMD = −1.26, 95% CI [−1.83, −0.68], Z = 4.31, P < .0001); However, the effects between yoga and pilates group were not significant difference (subtotal effect: SMD = −0.18, 95% CI [−0.76, 0.39], Z = 0.63, P = .53), either in yoga and complementary and alternative medicine (CAM) group (subtotal effect: SMD = −2.4, 95% CI [−5.26, 0.46], Z = 1.65, P = .10) (Fig. 3 A).

Figure 3:
Primary outcomes. (A) The overall effects of yoga and control for neck pain intensity. (B) The overall effects of yoga and control for pain-related disability. CI = confidential interval, M = mean, SD = standard deviation, SMD = standard mean difference.
Figure 3 (Continued):
Primary outcomes. (A) The overall effects of yoga and control for neck pain intensity. (B) The overall effects of yoga and control for pain-related disability. CI = confidential interval, M = mean, SD = standard deviation, SMD = standard mean difference.

3.4.2 Neck pain-related disability

The data from 8 trails[17,18,21–26] were pooled to find the effects of yoga on neck pain-related disability. As shown in Fig. 3 B, the effects of yoga were superior to the control group (total effect: SMD = −0.92, 95% CI [−1.38, −0.47], Z = 3.95, P < .0001). There were significant difference between the yoga and exercise group (subtotal effect: SMD = −0.97, 95% CI [−1.55, −0.38], Z = 3.24, P = .001), but no significant difference were found in yoga compares pilates (subtotal effect: SMD = −0.27, 95% CI [−0.88, 0.35], Z = 0.85, P = .39), and yoga compares CAM (subtotal effect: SMD = −2.31, 95% CI [−5.35, 0.73], Z = 1.49, P = .14).

3.5 Secondary outcomes

3.5.1 CROM

Three studies[23,24,26] compared the CROM changes after treatment between yoga and control groups. The meta analysis found that all the total and subtotal overall effects were statistical significant differences for CROM (total effect: SMD = 1.22, 95% CI [0.87, 1.57], Z = 6.83, P < .00001), flexion (subtotal effect: SMD = 1.46, 95% CI [0.44, 2.48], Z = 2.79, P = .005), extension (subtotal effect: SMD = 1.27, 95% CI [0.35, 2.20], Z = 2.69, P = .007), left lateral flexion (subtotal effect: SMD = 0.99, 95% CI [0.12, 1.87], Z = 2.22, P = .03), right lateral flexion (subtotal effect: SMD = 0.93, 95% CI [0.39, 1.47], Z = 3.37, P = .0007), and left rotation (subtotal effect: SMD = 1.37, 95% CI [0.09, 2.64], Z = 2.10, P = .04), except right rotation (subtotal effect: SMD = 1.24, 95% CI [−0.32, 2.80], Z = 1.55, P = .12) (Fig. 4 A).

Figure 4:
Secondary outcomes. (A) The overall effects of yoga and control for CROM. (B) The overall effects of yoga and control for QoL. (C) The overall effects of yoga and control for mood. CI = confidential interval, CROM = cervical range Of motion, M = mean, SD = standard deviation, SMD = standard mean difference, QoL = quality of life.
Figure 4 (Continued):
Secondary outcomes. (A) The overall effects of yoga and control for CROM. (B) The overall effects of yoga and control for QoL. (C) The overall effects of yoga and control for mood. CI = confidential interval, CROM = cervical range Of motion, M = mean, SD = standard deviation, SMD = standard mean difference, QoL = quality of life.

3.5.2 QoL

Three studies[22,24,25] pooled the effects of yoga compares exercise for CNNP on QoL. As shown in Fig. 4 B, the combined effect size showed a statistical significant difference (total effect: MD = 3.46, 95% CI [0.75, 6.16], Z = 2.51, P = .01). These 3 studies[22,24,25] stated that QoL improved in yoga group but no statistical significant difference in physical QoL in subgroup (subtotal effect: SMD = 2.24, 95% CI [−2.15, 6.64], Z = 1.00, P = .32), while significantly different in mental QoL (subtotal effect: SMD = 4.82, 95% CI [1.96, 7.69], Z = 3.30, P = .001).

3.5.3 Mood

Three studies[17,22,25] evaluated mood improvement and found statistical significance between the yoga and exercise (total effect: SMD = −0.61, 95% CI [−0.95, −0.27], Z = 3.53, P = .0004) (Fig. 4 C). Subgroup analysis shown that both depression and anxiety improved (subtotal effect: SMD = −0.63, 95% CI [−1.19, −0.07], Z = 2.19, P = .03; subtotal effect: SMD = −0.59, 95% CI [−1.09, −0.08], Z = 2.27, P = .02, respectively).

4 Discussion

4.1 Main findings

In this meta-analysis, 10 trails consisting of 686 participants were used to evaluate the effects of yoga and control for CNNP. According to the result, yoga had a positive effect on neck pain intensity, pain-related functional disability, CROM, QoL, and mood.

The results of this review related to pain, disability, QoL, and mood are generally consistent with the previous review.[15] In this study, we grouping the control intervention as pilates, exercise, and CAM (including acupuncture and Tai Chi in this study). The results indicate that all the above outcomes improved in yoga group, and there were significant difference in neck pain intensity between yoga and exercise group, neck pain-related disability between yoga and exercise group, mental QoL, depression, and anxiety. However, the effects of yoga with pilates or CAM for neck pain intensity and neck pain-associated disability were uncertain with a limited studies (3 and 2 studies, respectively). We also assessed the effects of yoga on CROM, which is one of the most basic indicators to evaluate the function of cervical vertebra,

Our results showed that yoga was superior to exercise to improve the CROM with a significant difference in flexion, extension, left lateral flexion, right lateral flexion, and left rotation, while this evidence was limited with only 3 included studies studied CROM.

In this meta-analysis, all of the included studies evaluated the immediate (<1 week) and short-term (1–12 weeks) outcomes, only 2[20,23] followed-up to 6 months, and one[20] followed-up to 12 months, which was not long enough to capture valid data. Thus, the results of this study only represent immediate-term and short-term effects.

Because of the limited studies, we cannot perform further subgroup analysis to explore the effects of different yoga styles, outcome measurements instruments, and follow-up terms, these differences in included studies might contribute to the significant between-study heterogeneity. It also remains unclear whether there are different effects of yoga on CNNP between countries and cultures, the 10 studies included in this review originated from 7 different countries, we were unable to conduct a meta-analysis to compare the effects. Previous studies have shown, however, that Indian studies on yoga tend to be more positive than those from other countries.[31] Nonetheless, we believe that this study included a representative study of the yoga for CNNP research in global.

There are robust evidences for the effects of yoga on CNNP to help improve mental QoL and mood, this finding is encouraging for certain patient groups, such as high stress-induced neck pain patients.

4.2 Strengths of the study

To the best of our knowledge, this is the first meta-analysis evaluating the effect of yoga on CROM in CNNP, which is important to assess the function of neck vertebrae. Another strength of our study is that we addressed a comprehensive search strategy of MeSH and non-MeSH terms both in Chinese and English databases to identify the overall publications on the subject. Furthermore, the literature search, study selection, quality assessment, and data extraction were all completed independently by 2 reviewers.

4.3 Weaknesses of the study

There are several limitations to this study. First, although we addressed a relatively multiple search strategy, we might still have missed some studies, especially non-English and non-Chinese studies, in the future meta-analysis, including more trails from India-origin of yoga were recommended. Secondly, the quality of original articles was not high and the sample size was limited. This may affect the reliability of the results to some extent. Thirdly, not being able to blind the participants may affect the validity of these results, since it is generally regarded impossible to blind patients and therapists in trials of behavioral interventions such as yoga.

4.4 Recommendations for future research

The sample size of original articles should be increased and the quality should be enhanced in future research. In this study, only 8 RCTs[17,18,20,22–26] and 2 q-RCTs[19,21] met the criteria and were included in the meta-analysis after quality assessment although we made a comprehensive search strategy of the Chinese and English databases, the average sample size of these studies was only 68.8. The outcome should also be fully reported, all 10 studies[17–26] reported neck pain intensity, 8[17,18,21–26] reported neck pain-related disability, but only 3 studies[23,24,26] reported the CROM, 3[22,24,25] reported QoL, and 3[17,22,25] reported mood. Furthermore, the characteristics, the intervention program, and the outcome measurements instruments of the studies were different, which may increase the heterogeneity of the studies, so a “gold-standard” yoga intervention criteria is also a priority in the future.

5 Conclusion

Because it was difficult to make a comprehensive summary of all the evidences due to the different session and duration of the yoga interventions, and the different outcome measurement tools in the study, we draw a very cautious conclusion that yoga can relieve neck pain intensity, improve pain-related function disability, increase CROM, improve quality of life, and boost mood. Therefore, more research on yoga for CNNP, specifically “gold-standard” yoga intervention, large-scale, high-quality RCTs on short-term as well as longer term outcomes, are urgently needed.


The authors thank Professor Honghong Wang, deputy dean of Xiangya Nursing School of Central South University for guidance. The authors also would like to thank Central South University, as well as Science and Technology Department of Hunan Province for their financial support. The fund supporters did not participate in the design, implementation, and writing of this paper. We also would like to thank Editage [www.editage.cn] for English language editing.

Author contributions

Conceptualization: Yunxia Li, Siyuan Li, Jieqiong Jiang.

Data curation: Yunxia Li, Siyuan Li, Jieqiong Jiang.

Formal analysis: Siyuan Li, Jieqiong Jiang.

Funding acquisition: Yunxia Li, Sue Yuan.

Investigation: Yunxia Li, Siyuan Li.

Methodology: Yunxia Li, Siyuan Li, Jieqiong Jiang.

Project administration: Yunxia Li, Sue Yuan.

Resources: Yunxia Li, Siyuan Li, Jieqiong Jiang.

Software: Yunxia Li, Siyuan Li, Jieqiong Jiang.

Supervision: Yunxia Li, Sue Yuan.

Validation: Sue Yuan.

Visualization: Sue Yuan.

Writing – original draft: Yunxia Li, Siyuan Li, Jieqiong Jiang, Sue Yuan.

Writing – review & editing: Yunxia Li, Siyuan Li, Jieqiong Jiang, Sue Yuan.


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chronic; meta-analysis; musculoskeletal; neck pain; nonspecific; systematic review; yoga

Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc.