Because the laboratory results raised concerns of NMS or a central nervous system (CNS) infection, sulpiride, alprazolam, and trazodone were discontinued due to clinically suspicious NMS. Contrast magnetic resonance imaging of the brain revealed abnormalities consistent with those of diffuse meningitis. A CSF sample demonstrated pleocytosis with neutrophil predominance, a high protein level, and a low glucose level (Table 2). The CSF culture yielded B pseudomallei. Accordingly, intravenous ceftazidime (2 g/8 h for 3 weeks) was administered, which resolved the symptoms. In-hospital treatment was followed by co-trimoxazole and minocycline outpatient treatment.
Several risk factors have been established as associated with melioidosis, including diabetes, chronic kidney disease, malignancy, and alcohol consumption. Occasionally, as in our patient who denied any prior systemic diseases, the risk factors may be absent. Although melioidosis can affect any organ in the body, the 2 most common clinical manifestations are pneumonia and bacteremia. Here, we reported the case of a patient with neurological melioidosis, which is relatively rare in the literature. According to the Darwin study, the incidence of CNS involvement in melioidosis is 3%. Previous studies have reported that approximately 1.5% to 2% of the patients with melioidosis in Southeast Asia exhibit neurological involvement.[6,7] In another study in Taiwan, male predominance was noted (male:female = 4:1), and CNS involvement was identified in 1.7% of melioidosis cases.
Our patient presented with the symptoms of an altered level of consciousness, high fever, muscle rigidity, and dysautonomia, which mimicked the features of NMS. However, these conditions could also present in many other clinical situations, including thyrotoxicosis or CNS infection. Although NMS is most often associated with first-generation antipsychotics such as haloperidol or fluphenazine, cases involving low-potency and second-generation antipsychotic drugs have also been reported.[8,9] Of note, age and sex are not risk factors of NMS. While NMS is mostly diagnosed in young adult males in the majority of studies, it is related to the population distribution of the exposure to neuroleptic agents. Although the possibility of developing NMS 30 days after the initiation of neuroleptic medication is less likely, it was observed in 4% cases by Caroff and Mann. Our patient was medicated with sulpiride, a low-potency antipsychotic drug, for over 2 years. She had not previously presented with any NMS symptoms, and NMS was unlikely based on the time course of her medical history. Moreover, a series of examinations resulted in the diagnosis of acute bacterial meningitis upon the positive culture of B pseudomallei from CSF.
On the basis of a Dutch study, 95% of patients with meningitis displayed at least 2 of the following 4 symptoms: fever, headache, neck stiffness, and altered mental status. In the Darwin Prospective Melioidosis Study, headache was prominent on admission in the majority of cases. Furthermore, of the patients who developed neurological complications, approximately 50% demonstrated some evidence of neck stiffness. Our patient presented with an altered level of consciousness, high fever, and headache, which are 3 of the 4 characteristic symptoms of bacterial meningitis. However, she also presented with generalized muscle rigidity, a rarity in neurological melioidosis. Muscle rigidity is a characteristic sign of extrapyramidal symptoms (EPS), which are drug-induced disorders caused by a dopamine blockade or depletion in the basal ganglia, frequently resulting from antipsychotic usage. In patients with long-term antipsychotic treatment, EPS might mislead or affect the physicians’ clinical ability to identify neck rigidity as a potential harbinger of meningitis. In addition, to the best of our knowledge, to date, there has only been 1 reported case of EPS following melioidosis in a patient who was not using antipsychotics, with the conclusion that the pathophysiological mechanism appeared to be secondary to the immunological response rather than as the result of direct CNS infiltration. Therefore, meningitis should not be dismissed in patients with fever of an unknown origin and undergoing long-term antipsychotic treatment because they may not present with the cardinal features of bacterial meningitis.
This case highlights the diagnostic challenge posed by melioidosis in patients treated with antipsychotics because it is a great mimicker of other diseases, manifesting as miscellaneous clinical symptoms and causing a potentially fatal outcome. From 2000 to 2005, the mortality rates regionally varied, with 22%, 33% to 65%, 9.5%, and 14% in Southern Taiwan, the Southeast Asia region, India, and Northern Australia, respectively. Furthermore, 16% to 19% of patients with inappropriate empirical therapy died before the confirmatory diagnosis of melioidosis.[1,2] Melioidosis is endemic to Southern Taiwan, and antipsychotic use might mask its symptoms. Therefore, physicians dealing with patients from an endemic area with a medical history of antipsychotics should always consider the possibility of neurological melioidosis and provide suspicious cases with prompt empirical management.
We acknowledge the support and help of all medical, nursing, and health worker colleagues who were involved in patient care and follow-up. We also acknowledge the expertise of the microbiology laboratory staff in Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, in identifying B pseudomallei.
Conceptualization: Guan-Bo Chen, Wen-Sou Lin.
Supervision: Li-Hsiang Chen, Wen-Sou Lin.
Writing – original draft: Guan-Bo Chen.
Writing – review & editing: Guan-Bo Chen, Sheng-Hui Tuan, Li-Hsiang Chen, Wen-Sou Lin.
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Keywords:Copyright © 2018 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.
Burkholderia pseudomallei; neuroleptic malignant syndrome; neurological melioidosis