The deep-rooted pathogenesis of the human papilloma virus (HPV) infection is still uncertain and argumentative. As we know, a lot of cases of esophageal infections, such as esophageal squamous cell carcinoma (ESCC) and esophageal squamous papilloma (ESP), associated with HPV are reported. However, primary esophageal ulcer infection associated with HPV is unusual.
This case is different from the other reports associated with HPV due to the patient's favorable prognosis.
We present a case of a man diagnosed in the Gastroenterology Department of Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, which presented a deep and big esophageal ulcer with irregular borders caused by type 16 HPV infection.
The esophageal ulcer was treated with vidarabine monophosphate treatment.
The esophageal ulcer was cured.
We could put forward the diagnostic criteria available for diagnostic guidelines and 2 hypotheses that could possibly prevent esophageal carcinoma from happening.
aDepartment of Gastroenterology, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine
bDepartment of Diabetes, Tianjin Nankai District Hospital of Traditional Chinese Medicine
cDepartment of Preventive Treatment of Disease, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Correspondence: Ning Jia, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine, Tianjin 300100, China (e-mail: China.email@example.com).
Abbreviations: ESCC = esophageal squamous cell carcinoma, ESP = esophageal squamous papilloma, HIV = human immunodeficiency virus, HPV = human papilloma virus, NBI = narrow band imaging, UGIE = upper gastrointestinal endoscopy.
NJ and YL contributed equally to this work.
The manuscript is approved by all the authors for publication. I would like to declare on behalf of my coauthors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part.
Tianjin Hospital of Integrated Traditional Chinese and Western Medicine's Ethics Committee approved the study.
Patient consent was given.
The authors declare that there is no conflict of interest regarding the publication of this article.
This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
Received November 2, 2017
Received in revised form November 15, 2017
Accepted November 16, 2017