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Research Article: Observational Study

Comparison of the Pentax AirwayScope and McGrath MAC videolaryngoscope for endotracheal intubation in patients with a normal airway

Lee, Jiyoung MDa; Kwak, Hyun Jeong MDb; Lee, Ji Yeon MDb; Chang, Min Young MDc; Lee, Sook Young MDc; Kim, Jong Yeop MDc,*

Editor(s): Bellou., Abdelouahab

Author Information
doi: 10.1097/MD.0000000000008713
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1 Introduction

Videolaryngoscopes (VLs) were created by combining features of classic laryngoscopes and fiber-optic bronchoscopes. VLs facilitate tracheal intubation by providing a superior view of the larynx without aligning the oral-pharyngeal-laryngeal axes.[1–4] VLs also decrease the incidence of intubation difficulties, increase the overall success rate of intubation,[2,5] and facilitate the training of inexperienced practitioners.[6]

The Pentax AirwayScope (AWS) (Pentax, Tokyo, Japan) consists of a disposable polycarbonate blade, a liquid crystal display (LCD) monitor, and an image tube with a camera. The blade of the Pentax AWS has 2 channels for the insertion of an endotracheal tube (ETT) and a suction catheter,[7] and its curved shape conforms to the anatomy of the upper airway. After inserting the blade into the patient's mouth and aligning the target signal on the screen with the glottic opening, an ETT can be directed through the vocal cords without additional handling.[8] The McGrath VL (Aircraft Medical, Covidien LLC, Mansfield, MA) is a portable device with an angulated single-use blade of adjustable size and an LCD monitor mounted on top of the handle.

Both the Pentax AWS and the McGrath VL offer a better laryngeal view and are helpful in managing difficult airways[2,5,9,10]; however, better visualization of the larynx does not always guarantee successful intubation or a shorter intubation time.[3,11,12] A prior study using manikins with normal airway models demonstrated a shorter intubation time with the Pentax AWS compared with the McGrath VL.[13] To date, however, no clinical study has directly compared the Pentax AWS with the McGrath VL in patients with normal airways. Therefore, we conducted a prospective, randomized trial that compared the Pentax AWS and the McGrath VL with respect to laryngeal view, intubation time, and ease of intubation in adult patients with normal airways.

2 Methods

This study was approved by the institutional review board of Ajou University Hospital, Suwon, Korea (AJIRB-DEV-OBS-16–473) and registered at (NCT 02997488). We obtained written informed consent from all patients involved in this study. We prospectively recruited 140 patients between the ages of 19 and 65, American Society of Anesthesiologists physical status I or II, who were scheduled for elective surgery requiring orotracheal intubation. The patients’ weight, height, Mallampati score, inter-incisor distance with maximal mouth opening, thyromental distance, cervical spine mobility (normal, reduced, or fixed), and upper incisor status (normal, absent, or prominent) were assessed preoperatively. Patients were excluded from this study if there was a suspected difficult airway (Mallampati score 4), known cervical spine injury, the need for rapid sequence induction, morbid obesity (body mass index >40 kg/m2), or the need for emergency surgery. Ultimately, 140 patients qualified for this study and were randomly assigned to either the Pentax AWS or McGrath VL group; randomization (1:1) was based on a computer-generated random numbers table.

Patients did not receive premedication prior to surgery. In the operating room, standard monitoring was used for all patients, including pulse oximetry, electrocardiography, noninvasive blood pressure monitoring, and the bispectral index (BIS) with a BIS Quattro sensor (Covidien LLC). Three minutes after preoxygenation, we induced anesthesia with fentanyl 0.5 to 1.5 μg/kg, propofol 1.5 to 2.0 mg/kg, and rocuronium 0.6 to 1.0 mg/kg. After induction of anesthesia, the patients’ lungs were ventilated with 100% oxygen. About 2 minutes after rocuronium injection, orotracheal intubation was performed with adequate neuromuscular blockade. Patients were intubated by 1 of the 2 anesthesiologists, both of whom had >10 years of clinical experience and had performed at least 20 successful intubations using both VL devices. The vocal cords and ETT insertions were visualized using the monitor of the Pentax AWS or the McGrath VL; ETTs with an inner diameter of 7.0 mm were used for both male and female patients. Approximately 60° angulated stylets (Mallinckrodt intubating stylet, Covidien, Ireland) were used as per the manufacturer's recommendation for the McGrath VL group. The primary outcome variable was time to intubation (TTI), defined as the time from inserting the blade between the patient's incisors to the first appearance of end-tidal carbon dioxide on the capnograph. An observer who was blinded to the patient group continuously watched a monitor to measure the TTI; another investigator performed optimal external laryngeal manipulation (OELM) to facilitate intubation if requested. If the intubation attempt took longer than 60 seconds or the patient's oxygen saturation (SpO2) dropped below 95%, a different method of intubation would be performed following mask ventilation and the VL intubation would be deemed a failure. The operator recorded the Cormack-Lehane (CL) glottic view classification,[14] percentage of glottic opening (POGO) scale,[15] intubation difficulty scale (IDS),[16] and the ease of intubation (5-point numerical rating scale). The operator also noted oropharyngeal bleeding if the VL blade was blood-tinged or if the patient showed signs of mucosal bleeding; bleeding was graded as none, trace, moderate, or severe. Patients were evaluated for sore throat and hoarseness in the post-anesthesia care unit (PACU). Mean arterial pressure, heart rate, SpO2, and BIS were recorded before induction of anesthesia, 1 minute after induction, before intubation, and 1 minute after intubation.

2.1 Statistical analysis

To estimate the sample size, we used the mean TTI and standard deviation (SD) from a previous study in our hospital, which were 30 and 10 seconds, respectively.[17] We assumed a between-group difference in TTI of 5 seconds to be clinically significant. The sample size was calculated to be 64 per group at 80% power and a significance level of 0.05; we recruited 140 patients to compensate for possible dropouts. All statistical analyses were performed using SPSS, version 23.0 for Windows (IBM Corp, Armonk, NY). We used the Mann-Whitney U test for the TTI, IDS, and POGO scale. The independent t test was used for the other continuous data, and the chi-square or Fisher exact test was used for categorical data between groups. Data are shown as median (interquartile range [IQR]), mean ± SD, or number of patients. Results were considered statistically significant when P <.05.

3 Results

A total of 140 patients completed this study (Fig. 1). The patient demographics and preoperative airway assessment findings were similar between the 2 groups (Table 1).

Figure 1
Figure 1:
Patient allocation flow diagram.
Table 1
Table 1:
Patient characteristics.

All patients were successfully intubated on the first attempt within 60 seconds. The results of the CL grade (1/2a/2b) (63/7/0 vs 43/24/3, P < .001), POGO scale (median [IQR]) (100 [100–100] vs 100 [80–100], P < .001), and IDS (median [IQR]) (0 [0–0] vs 0 ([0–1], P < .001) showed significantly better laryngeal visualization with the Pentax AWS compared with the McGrath VL. OELM was used for 5 patients in the McGrath VL group, whereas it was not performed at all in the Pentax AWS group; however, this difference was not statistically significant (P = .058). Moreover, ease of intubation (1–5-point NRS: 17/44/7/2/0 vs 18/43/9/0/0, P = .661) and the TTI (median [IQR]) (30 [27–34] vs 32 [27–35] seconds, P = .440) were similar between the Pentax AWS and McGrath VL groups (Table 2 and Fig. 2).

Table 2
Table 2:
Intubation profiles.
Figure 2
Figure 2:
Box plots illustrating time to intubation (TTI) (A), intubating difficulty scale (B), and percentage of glottic opening (C) in the Pentax and McGrath groups. The horizontal line in the box, the outer horizontal lines of the box, and error bar indicate median, IQR, and 95% confidence interval (CI), respectively. Open circles and asterisks are outliers and extreme outliers.

Table 3 shows no significant differences in hemodynamic changes or BIS values during anesthesia induction between the 2 groups.

Table 3
Table 3:
Hemodynamic changes during anesthesia induction.

4 Discussion

This study showed the Pentax AWS was overwhelmingly superior with respect to glottic view and the POGO scale in patients with normal airways; however, using the Pentax AWS did not improve the ease of intubation, TTI, or first-attempt success rate compared with the McGrath VL. This is the first randomized clinical trial to compare routine intubation using the Pentax AWS and the McGrath VL. Further studies might be needed to compare these 2 VL devices in patients with difficult airways or cervical spine immobilization.

In general, most VLs can improve laryngeal visualization.[1,3,4] In a study using manikins with normal airway models, the Pentax AWS and McGrath VL showed a CL grade 1 view 96% and 91% of the time, respectively.[13] In another study using a manikin model with an immobilized cervical spine, the Pentax AWS and McGrath VL shows a CL grade 1 view 100% and 82.6% of the time, respectively.[18] In this study, using patients with normal airways, a CL grade 1 view was achieved significantly more often with the Pentax AWS compared with the McGrath VL (90.0% vs 61.4%). Levitan et al[19] measured a grid of dark squares and found that the Pentax AWS has a vertically longer view than the McGrath VL, which has slightly smaller view, and this can partly contribute to the superior laryngeal view of the Pentax AWS.

A better glottic view by VLs does not always guarantee an easy intubation.[3,11,12] The pharyngeal-laryngeal-tracheal axes are not aligned during intubation with the McGrath VL, and the stylet must often be bent more acutely than the conventional 35° “hockey stick” angle to enter the glottis that presents anteriorly,[2,20] which can prolong the TTI. In contrast, the Pentax AWS has an anatomically shaped blade and a channel for the ETT, which makes guiding the tube into the glottic opening quite easy.[8] The Pentax AWS was reported to have intubation times that were shorter than or similar to the McGrath VL in previous manikin studies.[13,18,21,22] Sharma et al[13] reported that anesthetists unfamiliar with videolaryngoscopy demonstrated higher intubation success rates and a greater ability to rapidly secure the airway with the Pentax AWS compared with the McGrath VL in normal airway models. Other manikin studies also found that the TTI using the McGrath VL was significantly longer compared with other VLs, including the Pentax AWS; that study used a chest compression, immobilized cervical spine, and car victim model to simulate various difficult intubation situations.[18,21,22] In contrast, Komasawa et al[23] found that the intubating time was longer with the Pentax AWS compared with the McGrath VL in patients who received cricoid pressure during intubation; the authors explained that this was due to the McGrath VL providing both an indirect and direct glottic view, whereas the Pentax AWS only provided an indirect view by video camera.

In this study, the Pentax AWS showed a similar TTI despite the superior laryngeal view compared with the McGrath VL. One possible explanation of our results is that the operators in this study have mostly used a Macintosh laryngoscope, which visualizes the glottis in a similar way to the McGrath VL; both apply pressure to the hyoepiglottic ligament at the vallecula, indirectly lifting the epiglottis. In contrast, the blade of the Pentax AWS is designed to directly lift the whole epiglottis to align the tube with the target sign on the LCD monitor.[19] A review article by Hoshijima et al[24] demonstrated that the Pentax AWS offered a superior glottic view than a Macintosh laryngoscope, but this was not associated with a shorter TTI. Another possible explanation for these results is that careful insertion and removal of the bulky blade of the Pentax AWS without touching the teeth took more time than insertion and removal of the McGrath VL. A previous review article discovered that there were more dental clicks and dental compression with the Pentax AWS.[24] If we had measured time separately, the time from sighting the glottis to passing the ETT through the vocal cords would have been much shorter in the Pentax AWS group compared with the McGrath VL group.

In this study, the median (IQR) TTI by 2 experienced anesthesiologists was 30 (27–34) seconds in the Pentax AWS group and 32 (27–35) seconds in the McGrath VL group; this is comparable with findings from previous studies. With the Pentax AWS, Hirabayashi et al[9] reported that the mean TTI by non-anesthesiology residents was 44 seconds; Teoh et al[25] reported a median TTI of 18.9 seconds by anesthesiologists who had used the Pentax AWS at least 30 times previously. With the McGrath VL, Walker et al[26] reported that the median TTI was 47 seconds by inexperienced anesthesiologists, and Shippey et al[5] reported that median TTI was 24.7 seconds by experienced anesthesiologists. The different definition of TTI in each study might have influenced the results.

The Pentax AWS has a channel with which to guide the ETT; therefore, the lack of a stylet and the ability to continuously observe the intubation procedure can reduce the risk of oral and pharyngeal injury, including mild mucosal bleeding and sore throat.[10,27] We therefore expected fewer patients would experience oropharyngeal bleeding, sore throat, and hoarseness in the Pentax AWS group. Our results showed fewer patients had sore throat (14.3% vs 24.3%) and hoarseness (12.9% vs 20.0%) in the Pentax AWS group compared with the McGrath VL group; however, there were no statistically significant difference between the groups with comparable cuff pressure. Furthermore, the incidence of oropharyngeal bleeding was very rare in both groups; there was only 1 case with trace bleeding in the Pentax AWS group and there were no cases with bleeding in the McGrath VL group.

As matters stand today, the main challenges are to determine to what extent it should be used for routine clinical practice and to determine which devices are the best. Several editorialists insist VLs are the first line device for unanticipated difficult intubation.[3] However, the first line use of VLs for routine tracheal intubation is still controversial even though VLs reduce the risk of difficulties and eliminate the need for the intubating anesthesiologist to stop to exchange with another device.[1,11] In our study, the Pentax AWS and McGrath VL showed similar TTI and first-attempt success rates for routine clinical practice, so choosing between the 2 devices depends on the availability at the individual facilities and the anesthesiologist's familiarity.

This study has several limitations. First, it was not possible to blind the intubating anesthesiologist as to which airway instrument was being used. Second, the anesthesiologists in this study were much more familiar with the McGrath VL, which is similar to the blade of the Macintosh laryngoscope, so they took relatively longer to intubate with the Pentax AWS than what was initially expected. Given the Pentax AWS visualizes the glottis similarly to the Miller laryngoscope, if the operators in this study had mostly used a Miller laryngoscope for routine intubation, the intubating time using the Pentax AWS may have been different.

In conclusion, the Pentax AWS provided a significantly better glottic view compared with the McGrath VL; however, intubation times and ease of intubation were similar using both devices in patients with normal airways.


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anesthetic technique; McGrath Videolaryngoscope; Pentax AirwayScope

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