The construct of medication adherence comprises a set of inter-related health behaviors.1 One of these behaviors, the act of filling a medication prescription, can be estimated objectively using electronic databases such as electronic insurance claims or pharmacy dispensing databases. Numerous studies have assessed patterns of prescription refills among individuals who obtain at least 1 fill of a medication.2–11 Over the last several years, advances in electronic prescribing and medication order entry within the electronic health record (EHR) have expanded our ability to assess whether or not patients obtain their initial prescriptions, another of the health behaviors within the adherence cluster.12–17 Although EHR prescribing databases vary in whether or not they contain information on dispensed prescriptions, their use can enhance widely available pharmacy dispensing and pharmacy insurance claims database to better describe the sequence of behaviors that are necessary to achieve desirable treatment outcomes.
The addition of this new source of information about prescription-filling emphasizes the long-recognized lack of uniform terminology and precise definitions to describe prescription-filling behavior.18,19 Organizations such as the International Society for Pharmacoeconomics and Outcomes Research and the World Health Organization have put forward definitions of adherence and persistence; however, these definitions did not encompass the entire range of data sources for adherence. Further, existing definitions do not define terms consistently, do not address the issues of medications that are prescribed but not dispensed, and do not address behaviors such as medication discontinuation.20,21 Finally, adherence-related publications sometimes neither define their terms carefully nor explain their choice of metrics, leaving readers to make assumptions about why metrics were chosen and how they were calculated.
Applying a uniform conceptual framework to electronic database studies of medication adherence and employing standardized terminology and definitions within that framework will enhance both rigor and generalizability of medication adherence research, as well as the ability of researchers to formally compare the findings of studies in systematic reviews. In this paper, we propose a unifying set of definitions for use when studying prescription-filling for chronic oral medications in EHR, in pharmacy insurance claims databases, and in pharmacy dispensing databases and provide a framework to operationalize these definitions consistently across studies.
Literature Review of Chronic Oral Medication Adherence Definitions in Electronic Database Studies
The purpose of this literature review was to inform development of the conceptual model by identifying definitions and metrics for terms such as medication adherence, persistence, and discontinuation used in published studies based on electronic databases, and the rationale provided by the authors of these studies for selecting definitions and measurement tools. To accomplish this, 2 authors of the current paper (J.L.K. and M.A.R.) searched published literature to identify EHR, pharmacy dispensing, and pharmacy insurance claims-based studies where medication adherence, persistence, and/or discontinuation was stated as a primary outcome. Although the purpose of this review was narrowly focused and a comprehensive literature review was neither intended nor undertaken, the authors utilized search techniques from the literature on systematic reviews. Retrospective observational studies, randomized controlled trials, and nonrandomized comparative studies were included. The National Library of Medicine’s Medical Subject Headings (MeSH) keyword nomenclature developed for MEDLINE and adapted for use in other databases was employed. The search was limited to studies published in English from January 1, 2000 through December 15, 2011, and to articles indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Google Scholar, or the Web of Science. MeSH terms applied during the preliminary search were revised and refined based on expert input from a medical librarian and review of the MeSH terms identified from relevant publication titles retrieved in the preliminary search.
In the medical literature, the word adherence is applied to a broader variety of behaviors and regulatory topics than the focus of this work. Thus, studies that focused on adherence to or compliance with lifestyle, guidelines, exercise, diet, preventative screenings or follow-up, dental screenings/procedures, radiation/imaging, hospitalization/surgery, quality of care recommendations, medication reconciliation, drug administration/efficacy/adverse effects, device use, medical visits recommendations, isolation or hand washing precautions, cognitive/behavioral therapies, vaccination/immunization, and Health Insurance Portability and Accountability Act regulations were excluded. Moreover, we excluded studies that used the degree of risk factor control as the indicator of adherence, rather than directly measuring medication use or nonuse.
The title of each citation retrieved was reviewed and the abstract retrieved if the title indicated adherence or persistence to, or discontinuation of, chronic oral medications was the focus. Abstracts of articles dealing with validation of adherence measures used in electronic database studies were also included. Potentially relevant citations were imported into an electronic database. Abstracts of these citations were reviewed and the full texts of relevant articles were retrieved and read by the 2 individuals who conducted the literature search (M.A.R. and J.L.K.). As articles were read, the definitions and terminology used for adherence, persistence, and/or discontinuation in the articles were extracted and cataloged.
This literature scan retrieved 2484 articles, 315 (13%) of which utilized electronic data sources that included as the primary outcome chronic oral medication adherence or that evaluated adherence metrics. Studying the definitions and terminology we extracted from these publications confirmed our subjective impression of variation, inconsistency, and confusion in the terminology used. It also demonstrated that terms were used imprecisely and interchangeably to refer to different constructs in different papers. This background work reinforced the fact that a conceptual model of and uniform definitions for the adherence continuum were lacking. It also informed the standardized terminology and definitions we developed (Tables 1 and 2).
Developing the Conceptual Model of Standardized Terminology and Definitions of Medication Adherence for Electronic Database Methods
The overall intent of developing a conceptual model was to set out on a series of general definitions that could be broadly applied across the fields of electronic data methods and medical informatics and that were applicable in estimating adherence to oral medications for chronic diseases. These definitions were intended to encompass the many opportunities for patients to accept or decline medication within the prescribing and dispensing components of the adherence, persistence, and discontinuation continuum of behaviors. In developing the conceptual model, we applied the following principles: (1) develop a clear, concise, and broadly applicable model that described a sequence of discrete behaviors overtime; (2) articulate key constructs and subconstructs of the continuum; (3) express and organize categories in a logical and systematic manner; (4) provide sufficient detail to clarify the approach and enable its use; and (5) avoid restricting appropriate study-specific decisions (eg, observation windows).
Adherence and persistence definitions require study-specific decisions to yield operational definitions of, for example, the period of observation (observation window), the patient sample under study, and the period over which the prescription must be filled after the initial order is written. The duration of the observation window is often conditional on the context, type of medication or disease state, unique details (eg, usual days’ supply of drug dispensed), and selection criteria (eg, patients with at least 2 dispensings). Other study-specific decisions often include specifying an observation timeframe after the medication was dispensed as well as measurement metrics and tools such as formulas to calculate medication possession or gaps in medication availability. The definitions outlined here are focused on the structure of the definitions rather than on the specifics of the operational definitions. However, some operational definitions are provided to remind researchers that these decisions must also be clearly documented. Although the primary focus of developing this conceptual model was to provide broadly applicable definitions, we also identify and classify existing metrics that enable use of these definitions. The Kaiser Permanente Colorado Institutional Review Board (IRB) determined that the activities involved in writing this paper met the federal and institutional criteria for exemption from IRB review.
Our proposed conceptual model, terminology, and definitions of medication adherence for electronic data–based methods (Fig. 1 and Table 1) is predicated on 2 key constructs: medication adherence and medication persistence. Adherence connotes the degree or extent to which the patient conforms to the medication use recommendations specified by the prescriber (eg, frequency/interval of administration, time of day ingested, strength of dosage).20 In contrast, persistence encompasses the time over which a patient continues treatment or continues to refill the prescription, from starting to stopping therapy.20,47
In this conceptual model (Fig. 1), adherence is subdivided into 2 main categories: primary adherence and secondary adherence. Primary adherence is a discrete event that assesses whether or not the patient received the first prescription. In contrast, secondary adherence is an ongoing process that measures whether or not the patient received dispensings or refills as prescribed during a defined observation period. Only after these adherence subconstructs have been acknowledged and assessed can the next level of secondary adherence—whether it is adequate or inadequate—be assessed. In these proposed definitions, the converse of each adherence term is simply “non” as in “primary nonadherence” and “secondary nonadherence.”
Medication persistence implies that the patient must have exhibited at least primary adherence because persistence over time cannot be measured unless the patient has received at least the first dispensing (Fig. 2). We propose that early-stage persistence be defined to include individuals with at least 2 dispensings and later-stage persistence as including individuals with 3 or more dispensings of the medication and with evidence of medication availability. For consistent terminology, we propose the converse of each persistence category to also be “non” as in “early-stage nonpersistence” and “later-stage nonpersistence.”
Medication discontinuation implies that a patient has terminated therapy as evidenced by not refilling a prescription, but no subjective inference regarding appropriateness is made, as discontinuation may be initiated either by the clinician or the patient. Further, in claims database studies, it is usually not possible to determine whether discontinuation was prescriber-initiated or patient-initiated. Medication discontinuation in electronic database studies can only be assessed within the context of a prespecified operational definition for the required number of days without medication available. Thus, very low measured levels of adherence (MPR or PDC<40%; CMG or NPMG>60%) can in some circumstances represent, or be confused with, discontinuation.
Metrics that have been used to calculate medication adherence and/or persistence using electronic databases are summarized in Table 2. In general, these metrics enable calculation of either medication possession (ie, possession measures) or gaps in medications availability (ie, gap measures)18,40,48,49 and most estimate adherence only among individuals with secondary adherence. Most metrics are continuous measures, but they are often categorized (eg, low or inadequate vs. moderate vs. high or adequate adherence). These measures require data including the date of medication dispensing, days’ supply dispensed with each dispensing, and previous (stockpiled) medications (or an indication that it will be set to 0) to estimate medication availability and consumption, usually estimated between the first and terminal dispensings within an observation window. A minority of metrics estimate availability within a single dispensing interval (eg, the continuous, single-interval measure of medication acquisition). The metrics also vary in whether or not the days’ supply dispensed with the terminal dispensing is included in the calculation. The time between any 1 dispensing and the subsequent dispensing is known as the refill interval. Person-time is censored at the last dispensing date, at the time of exhaustion of the last days’ supply, or at a fixed number of days after exhaustion of the last days’ supply. Most gap measures of secondary adherence censor after the last dispensing once stockpiled medications have been exhausted.
The 2 most commonly used secondary adherence medication possession measures are the medication possession ratio (MPR) and the proportion of days covered (PDC).18,40–42,44,47 Both report medication availability by estimating the proportion of prescribed days’ supply obtained during a specified observation period over refill intervals and both are becoming widely applied in health care settings50 in large part because they are easily calculated (a SAS macro has been written for MPR and PDC). For example, as operationalized by the Pharmacy Quality Alliance,50 the PDC has been endorsed by the National Quality Forum as a tool to measure health care quality.51 The main difference between the PDC and the MPR is that with the PDC any oversupply is truncated, whereas adherence values of >100% are allowed with the MPR. There is controversy about whether “over adherence,” often considered as MPR between 100% and 120%, has clinical meaning.41 A shortcoming of these (and other) secondary adherence measures is that, when integrating across several observation periods of multiple refills each, delayed dispensing(s) in 1 observation period can be numerically counterbalanced by early dispensing in a later observation period, thus potentially underascertaining adherence in 1 observation period and overestimating it in another. The converse can also occur. This drawback is of particular importance in longitudinal assessments where changes in adherence behavior are assessed across multiple observation periods by calculating the adherence metric separately within each period. Other strengths and weaknesses of the medication possession and gap measures are summarized in Table 2.
Because most measures of adherence require at least 2 dispensings, the least adherent patients (primary nonadherent) are excluded. Within the last few years, measures have been developed that include patients with either primary or secondary (non)adherence.6 One such metric, the New Prescription Medication Gap (NPMG) measure, is defined as the proportion of days within an interval bounded by the prescriber’s initial EHR prescription medication order date and the end of the observation period (or end of follow-up if censored or the therapy is switched or discontinued).6 As with older gap measures, NPMG is a continuous measure, ranging from 100% for patients who obtain no medication to 0% for those who consistently refill their medication in a timely manner. Unlike secondary adherence measures, NPMG was designed to evaluate medication supply starting at prescribing and ending at a fixed censoring point, thus comprehensively capturing (non) adherence for those who never start the prescribed medication or who discontinue it early as well as for those who have at least 2 dispensings. An additional strength of NPMG is that because it enables evaluation from the point of prescribing in the EHR, person-time can be censored if the prescriber switches or discontinues therapy and documents those orders in the EHR.
In this paper, we offer a standardized set of definitions and terminology for assessing medication adherence and persistence in electronic database studies, whether the databases employed are medications ordered within an EHR, medications dispensed and documented in a pharmacy database, or pharmacy claims processed through an insurance database. These conceptual models and terminology are more comprehensive than current, commonly used definitions. The models we propose include clear and systematic definitions of adherence, and persistence developed to facilitate EHR-based research are specific to medication adherence, and extend to adherence and persistence subcategories and medication discontinuation. We also point out the importance and utility of developing precise operational definitions for adherence research as these definitions enhance the precision of ascertaining whether a patient was likely exposed to a specific medication on a particular date for a specific research purpose (eg, on the date of some clinical measure, event, or outcome).
Research focusing on adherence is voluminous. As obtaining the initial prescription medication and taking the medication are prerequisite health behaviors for medication effectiveness, these are key explanatory variables when observed effectiveness is lower than the efficacy demonstrated in controlled trials. As a consequence, comparative effectiveness studies may be designed to evaluate the effectiveness of various interventions to improve these adherence behaviors in their own right. Meta-analytic studies are also useful in assessing adherence as an outcome, and the level of adherence necessary to achieve treatment goals. To facilitate these types of studies, it is critical that the adherence measure be accurately estimated and consistent across studies.
There are limitations to this work. Our conceptual model is specific to prescription-filling and has not been compared with frameworks for other prescription behaviors such as medication-taking.20,25 Definitions are only part of the decision-making process in adherence research. Many important methodological considerations that should be addressed were beyond the scope of this paper such as identifying clinically meaningful categorizations for adherence (eg,<20% CMG; ≥80% MPR) based on observed relationships between adherence and clinical outcomes for specific disease states, the role of informative censoring (eg, medication stop orders and switches), comprehensive assessment of discrete events (eg, appropriate timeframes to consider for medication discontinuation), and bias associated with assuming dispensing data are complete (eg, prescriptions transferred outside an integrated health care system, paying cash for prescriptions resulting in no prescription insurance claims being filed).
We offer a set of standardized medication adherence terminology and definitions for use with electronic database research. The medication adherence and persistence conceptual models and definitions we present will enable future meta-analytic and comparative effectiveness research, as standardized terminology facilitates rigorous comparisons. As such, this paper is foundational for adherence methods.
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