Methods Used by PRO SystemsEngaging Patients and Clinicians in Online Reporting of Adverse Effects During Chemotherapy for Cancer The eRAPID System (Electronic Patient Self-Reporting of Adverse Events: Patient Information and aDvice)Absolom, Kate PhD; Gibson, Andrea RN; Velikova, Galina MD, PhDAuthor Information Section of Patient Centered Outcomes Research, St James’ University Hospital, Leeds, United Kingdom This article presents independent research funded by the National Institute for Health Research (NIHR) under the Programme Grants for Applied Research programme (RP-DG-1209-10031 and RP-PG-0611-20008). The views expressed in this article are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. This paper is part of the PRO-cision Medicine Methods Toolkit paper series funded by Genentech. K.A. received an honorarium payment for their contribution. The PRO-cision Medicine Methods Toolkit paper series was presented during a symposium at the 2018 Annual Conference of the International Society for Quality of Life Research, Dublin, Ireland. The authors declare no conflict of interest. Reprints: Kate Absolom, PhD, Section of Patient Centered Outcomes Research, Level 6 Bexley Wing, St James’ University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom. E-mail: [email protected]. Medical Care: May 2019 - Volume 57 - Issue - p S59-S65 doi: 10.1097/MLR.0000000000001085 Buy Metrics Abstract Introduction: During cancer treatment the timely detection and management of adverse events is essential for patient safety and maintaining the quality of life. Electronic patient self-Reporting of Adverse events: Patient Information and aDvice (eRAPID) was devised to support oncology practice, by allowing patients to self-report symptoms online at home during and beyond cancer treatment. Fundamentally the eRAPID intervention delivers immediate severity-tailored feedback directly to patients to guide self-management strategies or hospital contact. Patient data are available in electronic health records for hospital staff to access and review as part of clinical assessments. Methods for Interpreting and Addressing Patient-Reported Outcome (PRO) Scores: The eRAPID intervention has 5 main interconnecting components (clinical integration into standard care pathways, patient symptom reports, self-management advice, information technology, and staff/patient training). Following guidance for the development of complex interventions and using a mixed methods approach, eRAPID was created through a number of stages and tested in a series of usability settings before undergoing systematic evaluation in a randomized controlled trial. These developmental stages are described here with a focus on how decisions were made to enhance patient and professional engagement with symptom reports and encourage interpretation and clinical utilization of the data. Discussion: Clinically embedded PRO interventions involve a number of elements and stakeholders with different requirements. Following extensive developmental work eRAPID was pragmatically designed to fit into current oncology practices for reviewing and managing chemotherapy-related toxicities. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.