IntroductionA PRO-cision Medicine Methods Toolkit to Address the Challenges of Personalizing Cancer Care Using Patient-Reported Outcomes Introduction to the SupplementSnyder, Claire PhD*,†,‡; Brundage, Michael MD, MSc§; Rivera, Yonaira M. MPH†; Wu, Albert W. MD*,†Author Information *Johns Hopkins School of Medicine †Johns Hopkins Bloomberg School of Public Health ‡Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD §Queen’s Cancer Research Institute, Kingston, ON, Canada This paper is part of the PRO-cision Medicine Methods Toolkit paper series funded by Genentech. All authors received funding support from Genentech through their institutions. Y.M.R. is also supported by the National Institutes of Health, National Research Service Award T32 CA009314. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The PRO-cision Medicine Methods Toolkit paper series was presented during a symposium at the 2018 Annual Conference of the International Society for Quality of Life Research, Dublin, Ireland. The authors declare no conflict of interest. Reprints: Claire Snyder, PhD, 624 N. Broadway, Room 649, Baltimore, MD 21205. E-mail: [email protected]. Medical Care: May 2019 - Volume 57 - Issue - p S1-S7 doi: 10.1097/MLR.0000000000001089 Buy Metrics Abstract Patients are increasingly being asked to complete standardized, validated questionnaires with regard to their symptoms, functioning, and well-being [ie, patient-reported outcomes (PROs)] as part of routine care. These PROs can be used to inform patients’ care and management, which we refer to as “PRO-cision Medicine.” For PRO-cision Medicine to be most effective, clinicians and patients need to be able to understand what the PRO scores mean and how to act on the PRO results. The papers in this supplement to Medical Care describe various methods that have been used to address these issues. Specifically, the supplement includes 14 papers: 6 describe different methods for interpreting PROs and 8 describe how different PRO systems have addressed interpreting PRO scores and/or acting on PRO results. As such, this “Methods Toolkit” can inform clinicians and researchers aiming to implement routine PRO reporting into clinical practice by providing methodological fundamentals and real-world examples to promote personalized patient care. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.