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Noninvasive ventilation in acute respiratory failure due to H1N1 influenza

A word of caution

Singh, Akashdeep; Singh, Jaspreet1

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doi: 10.4103/0970-2113.80340
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The case of acute respiratory failure due to H1N1 influenza managed by noninvasive ventilation (NIV) described by Mohapatra et al.[1] is very interesting, but there are few technical issues which need to be discussed.

First, the use of NIV in hypoxemic respiratory failure is controversial, and the etiology of hypoxemia appears to be an important determinant of its success. A meta-analysis[2] suggests that noninvasive positive-pressure ventilation (NPPV) does not decrease the need for intubation, so there is not enough evidence to support its use in acute respiratory distress syndrome. There are only a few patients with H1N1-related respiratory failure who seem to benefit from NIV alone, so it should be reserved for patients with milder disease. Guidelines endorsed by the European Respiratory Society and European Society of Intensive Care Medicine[3] conclude that, as a general rule, NIV should not be recommended as an alternative to invasive ventilation in patients affected by H1N1.

Second, NIV is a potential aerosol-generating device. In this regard, the deliberate leakage via the exhalation ports may generate droplet nuclei and disperse infective aerosols through the evaporation of the water content of respiratory droplets resulting in a superspreading event.[4]

A case–control study[5] involving 124 medical wards in 26 hospitals in Guangzhou and Hong Kong has identified SARS patients requiring NPPV as independent risk factors for spreading nosocomial outbreaks of SARS.

Keeping these two facts in mind, it is very difficult to justify NIV usage in patients with acute respiratory failure due to H1N1 influenza.


1. Mohapatra PR, Dutt N, Khanduri S, Mishra B, Janmeja AK. Noninvasive ventilation in acute respiratory failure due to H1N1 influenza Lung India. 2011;28:49–51
2. Agarwal R, Reddy C, Aggarrwal AN, Gupta D. Is there a role for noninvasive ventilation in acute respiratory distress syndrome? Respir Med. 2006;100:2235–8
3. Conti G, Larrsson A, Nava S, Navalesi P On the role of non-invasive (NIV) to treat patients during the H1N1 influenza pandemic. Available from: Availablefrom:
4. Tang JW, Li Y, Eames I, Chan PK, Ridgway GL. Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises J Hosp Infect. 2006;64:100–14
5. Yu IT, Xie ZH, Tsoi KK, Chiu YL, Lok SW, Tang XP, et al Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others? Clin Infect Dis. 2007;44:1017–25
© 2011 Lung India | Published by Wolters Kluwer – Medknow