Challenges in PracticeTopical Leptospermum Honey in the Management of Aplasia Cutis Congenita in Neonates A Case StudyBoyar, VitaAuthor Information Vita Boyar, MD, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Cohen Children's Medical Center of New York, New Hyde Park, New York; and Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York. Correspondence: Vita Boyar, MD, Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Cohen Children's Medical Center of New York, 269-01 76 Ave, Ste 344, New Hyde Park, NY 11040 (VBoyar@gmail.com). The authors declare no conflicts of interest. Journal of Wound Ostomy & Continence Nursing: July/August 2019 - Volume 46 - Issue 4 - p 343-345 doi: 10.1097/WON.0000000000000541 Buy Metrics Abstract BACKGROUND: Aplasia cutis congenita (ACC) is an uncommon, heterogeneous group of disorders characterized by focal or widespread absence of skin from certain parts of the body. Complications range from 20% to 50%; they are potentially life-threatening. There is no consensus on best treatment of ACC. We report on successful closure of aplasia cutis lesions using topical active Leptospermum honey (ALH). CASES: This article describes a case of a full-term neonate with a large ACC lesion. A conservative approach was taken in the care of this lesion, in accordance with appropriate wound care principles and the care of this medically fragile neonate. This included applying topical ALH twice a day and covering defects with a secure dressing. All lesions progressed to complete closure. Time to closure was either similar or shorter than published data. CONCLUSIONS: Our experience with these cases suggests that topical ALH may be an effective natural treatment option for neonates with ACC. This conservative management led to wound closure without topical or systemic antibiotics or prolonged hospital stay. © 2019 by the Wound, Ostomy and Continence Nurses Society.