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Collagenase for Enzymatic Debridement: A Systematic Review

Ramundo, Janet; Gray, Mikel

Journal of Wound, Ostomy and Continence Nursing: November-December 2009 - Volume 36 - Issue 6S - p S4–S11
doi: 10.1097/WON.0b013e3181bfdf83

Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice. This systematic review summarizes and ranks evidence concerning the safety and efficacy of the selective enzymatic debriding agent collagenase. Studies were identified comparing collagenase to inactive (sham) ointment and to alternate techniques for debridement including autolytic and surgical. A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds.

Janet Ramundo, MSN, RN, CWOCN, Emory University Wound Ostomy and Continence Nursing Education Program, Atlanta, Georgia.

Mikel Gray, PhD, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Professor and Nurse Practitioner, Department of Urology, University of Virginia, Charlottesville.

Corresponding author: Mikel Gray, PhD, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, PO Box 800422, UVA HSC, Charlottesville, VA 22908 (

Neither Dr. Ramundo nor Dr. Gray are affiliated with Healthpoint Ltd.

Copyright © 2009 by the Wound, Ostomy and Continence Nurses Society