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Collagenase Santyl Ointment: A Selective Agent for Wound Debridement

Shi, Lei; Carson, Dennis

Journal of Wound Ostomy & Continence Nursing: November-December 2009 - Volume 36 - Issue 6S - p S12–S16
doi: 10.1097/WON.0b013e3181bfdd1a

Enzymatic debridement is a frequently used technique for removal of necrotic tissue from wounds. Proteases with specificity to break down the collagenous materials in necrotic tissues can achieve selective debridement, digesting denatured collagen in eschar while sparing nonnecrotic tissues. This article provides information about the selectivity of a collagenase-based debriding agent, including evidence of its safe and efficacious uses. Recent research has been conducted, investigating the chemical and biological properties of collagenase ointment, including healing in animal models, digestion power on different collagen types, cell migration activity from collagen degradation products, and compatibility with various wound dressings and metal ions. Evidence presented demonstrates that collagenase ointment is an effective, selective, and safe wound debriding agent.

Lei Shi, PhD, Scientific Advisor, Research and Development, Healthpoint Ltd, Fort Worth, Texas.

Dennis Carson, PhD, DABT, Director, Research and Development, Healthpoint Ltd, Fort Worth, Texas.

Corresponding author: Lei Shi, PhD, Healthpoint Ltd, 3909 Hulen St, Fort Worth, TX 76107 (

Dr. Shi and Carson are employed by Healthpoint Ltd.

Copyright © 2009 by the Wound, Ostomy and Continence Nurses Society