Estradiol provokes hypercoagulability and affects fibrin biology: A mechanistic exploration of sex dimorphisms in coagulation Coleman, Julia R.; Moore, Ernest E.; Schmitt, Lauren; More Coleman, Julia R.; Moore, Ernest E.; Schmitt, Lauren; Hansen, Kirk; Dow, Nathan; Freeman, Kalev; Cohen, Mitchell J.; Silliman, Christopher C. Less Journal of Trauma and Acute Care Surgery. 94(2):179-186, February 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: The mechanism of sex dimorphisms in coagulation is unknown, but Coleman et al show that estradiol provokes hypercoagulability and changes clot proteomics and fibrin cross-linking. Should estradiol be used a therapeutic adjunct in coagulopathy resuscitation? #surgscience Go to Full Text of this Article Free CME Test SDC Infographic
Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density neutrophils after trauma Goretti Riça, Ingred; Joughin, Brian A.; Teke, Martha E.; More Goretti Riça, Ingred; Joughin, Brian A.; Teke, Martha E.; Emmons, Tiffany R.; Griffith, Alec M.; Cahill, Laura A.; Banner-Goodspeed, Valerie M.; Robson, Simon C.; Hernandez, Jonathan M.; Segal, Brahm H.; Otterbein, Leo E.; Hauser, Carl J.; Lederer, James A.; Yaffe, Michael B. Less Journal of Trauma and Acute Care Surgery. 94(2):187-196, February 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Can trauma influence neutrophil heterogeneity in circulating blood leukocytes? A study in human trauma patients shows that two unique neutrophil populations emerge after trauma which may have immunosuppressive properties. Buy SDC Infographic
Multicompartmental trauma alters bone marrow erythroblastic islands Kelly, Lauren S.; Munley, Jennifer A.; Pons, Erick E.; More Kelly, Lauren S.; Munley, Jennifer A.; Pons, Erick E.; Coldwell, Preston S.; Kannan, Kolenkode B.; Efron, Philip A.; Mohr, Alicia M. Less Journal of Trauma and Acute Care Surgery. 94(2):197-204, February 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Erythroblastic islands, niches for erythroblast maturation and red blood cell development, exhibit altered structure and cell composition after multicompartmental injury, hemorrhage, and stress in rats. Buy SDC Infographic
When is enough enough? Odds of survival by unit transfused Loudon, Andrew M.; Rushing, Amy P.; Hue, Jonathan J.; More Loudon, Andrew M.; Rushing, Amy P.; Hue, Jonathan J.; Ziemak, Alison; Sarode, Anuja L.; Moorman, Matthew L. Less Journal of Trauma and Acute Care Surgery. 94(2):205-211, February 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Transfusion is lifesaving. The Red Cross blood shortage in Jan 2022 threatened the immediate availability of blood. When blood is scarce, who benefits most from a unit? At 11U PRBC mortality = survival; 16U mortality > survival; >36U mortality is expected. Buy SDC Infographic
