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​​​Adjuncts to Massive Transfusion Protocols for Trauma Patients 


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Adjuncts to Massive Transfusion Protocols for Trauma Patients 
AAST Webinar, October 27, 2016

Presented by:
Dr. Joseph Rappold, Maine Medical Center/Tufts University School of Medicine, Portland, Maine

Moderated by:
Dr. Tyler Putman, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania


Referenced in presentation: 

Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX).
Eckert MJ, Wertin TM, Tyner SD, Nelson DW, Izenberg S, Martin MJ.
J Trauma Acute Care Surg. 2014 Dec;77(6):852-8; discussion 858.  ​

Do all trauma patients benefit from tranexamic acid?
Valle EJ, Allen CJ, Van Haren RM, Jouria JM, Li H, Livingstone AS, Namias N, Schulman CI, Proctor KG.
J Trauma Acute Care Surg. 2014 Jun;76(6):1373-8.

Tranexamic acid in trauma: how should we use it?
Napolitano LM, Cohen MJ, Cotton BA, Schreiber MA, Moore EE.
J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86.

Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.
Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF.
J Trauma. 2008 May;64(5):1211-7; discussion 1217.


Further reading: 

Intraluminal tranexamic acid inhibits intestinal sheddases and mitigates gut and lung injury and inflammation in a rodent model of hemorrhagic shock.
Peng Z, Ban K, LeBlanc A, Kozar RA.
J Trauma Acute Care Surg. 2016 Aug;81(2):358-65. 

Tranexamic acid as part of remote damage-control resuscitation in the prehospital setting: A critical appraisal of the medical literature and available alternatives.
Ausset S, Glassberg E, Nadler R, Sunde G, Cap AP, Hoffmann C, Plang S, Sailliol A.
J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S70-5.

Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid.​
Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, Silliman CC, Banerjee A.
J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S65-9.

The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis.
Harvin JA, Peirce CA, Mims MM, Hudson JA, Podbielski JM, Wade CE, Holcomb JB, Cotton BA.
J Trauma Acute Care Surg. 2015 May;78(5):905-9; discussion 909-11.

Tranexamic acid corrects fibrinolysis in the presence of acidemia in a swine model of severe ischemic reperfusion.
DeBarros M, Hatch Q, Porta CR, Salgar S, Izenberg S, DuBose J, Eckert M, Martin M.
J Trauma Acute Care Surg. 2014 Mar;76(3):625-32; discussion 632-3.

The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis.
Porta CR, Nelson D, McVay D, Salgar S, Eckert M, Izenberg S, Martin MJ.
J Trauma Acute Care Surg. 2013 Dec;75(6):954-60.

Tranexamic acid for trauma patients: a critical review of the literature.
Cap AP, Baer DG, Orman JA, Aden J, Ryan K, Blackbourne LH.
J Trauma. 2011 Jul;71(1 Suppl):S9-14.