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​The Role of Whole Blood and Massive Transfusion


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The Role of Whole Blood and Massive Transfusion
AAST Webinar, March 24, 2016

Presented by:
Dr. John Hess, University of Washington, Seattle, Washington
Dr. Phillip Spinella, Washington University in St. Louis, St. Louis, Missouri
Dr. Alan Murdock, Allegheny Health Network Medical Education Consortium, Pittsburgh, Pennsylvania

Moderated by:
Dr. Warren Dorlac, University of Colorado Health, Loveland, Colorado

Referenced in presentation:

Coagulation function of stored whole blood is preserved for 14 days in austere conditions: A ROTEM feasibility study during a Norwegian antipiracy mission and comparison to equal ratio reconstituted blood.
Strandenes G, Austlid I, Apelseth TO, Hervig TA, Sommerfelt-Pettersen J, Herzig MC, Cap AP, Pidcoke HF, Kristoffersen EK.
J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S31-8.

Further reading:

Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients.
Yazer MH, Jackson B, Sperry JL, Alarcon L, Triulzi DJ, Murdock AD.
J Trauma Acute Care Surg. 2016 Jul;81(1):21-6.

The safety of early fresh, whole blood transfusion among severely battle injured at US Marine Corps forward surgical care facilities in Afghanistan.
Auten JD, Lunceford NL, Horton JL, Galarneau MR, Galindo RM, Shepps CD, Zieber TJ, Dewing CB.
J Trauma Acute Care Surg. 2015 Nov;79(5):790-6.

All plasma products are not created equal: Characterizing differences between plasma products.
Spinella PC, Frazier E, Pidcoke HF, Dietzen DJ, Pati S, Gorkun O, Aden JK, Norris PJ, Cap AP.
J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S18-25.

Early autologous fresh whole blood transfusion leads to less allogeneic transfusions and is safe.
Rhee P, Inaba K, Pandit V, Khalil M, Siboni S, Vercruysse G, Kulvatunyou N, Tang A, Asif A, O'Keeffe T, Joseph B.
J Trauma Acute Care Surg. 2015 Apr;78(4):729-34.

Changes in gene expression following trauma are related to the age of transfused packed red blood cells.
Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O'Dwyer MJ.
J Trauma Acute Care Surg. 2015 Mar;78(3):535-42.

The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants.
Kornblith LZ, Howard BM, Cheung CK, Dayter Y, Pandey S, Busch MP, Pati S, Callcut RA, Vilardi RF, Redick BJ, Nelson MF, Cohen MJ.
J Trauma Acute Care Surg. 2014 Dec;77(6):818-27.

The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injury.
Brasel KJ, Vercruysse G, Spinella PC, Wade CE, Blackbourne LH, Borgman MA, Zarzabal LA, Du F, Perkins JG, Maegele M, et al.
J Trauma. 2011 Aug;71(2 Suppl 3):S343-52.​