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​Blood Transfusion: A Relatively New Frontier

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Blood Transfusion: A Relatively New Frontier
AAST Webinar, February 17, 2016

Presented by:
Dr. Martin Schreiber, Oregon Health & Science University, Portland, Oregon

Moderated by:
Dr. Timothy Fabian, University of Tennessee, Memphis, Tennessee​

Referenced in presentation:

Use of freeze-dried plasma in French intensive care unit in Afghanistan.
Martinaud C, Ausset S, Deshayes AV, Cauet A, Demazeau N, Sailliol A.
J Trauma. 2011 Dec;71(6):1761-4; discussion 1764-5.

Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw.
Pati S, Matijevic N, Doursout MF, Ko T, Cao Y, Deng X, Kozar RA, Hartwell E, Conyers J, Holcomb JB.
J Trauma. 2010 Jul;69 Suppl 1:S55-63.

Early coagulopathy predicts mortality in trauma.
MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M.
J Trauma. 2003 Jul;55(1):39-44.

Further reading:

Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients.
Yazer MH, Jackson B, Sperry JL, Alarcon L, Triulzi DJ, Murdock AD.
J Trauma Acute Care Surg. 2016 Jul;81(1):21-6.

The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury.
Howard BM, Miyazawa BY, Dong W, Cedron WJ, Vilardi RF, Ruf W, Cohen MJ.
J Trauma Acute Care Surg. 2015 Dec;79(6):1009-13; discussion 1014.

Syndecan-1 restitution by plasma after hemorrhagic shock.
Kozar RA, Pati S.
J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S83-6.

Cryopreserved red blood cells are superior to standard liquid red blood cells.
Hampton DA, Wiles C, Fabricant LJ, Kiraly L, Differding J, Underwood S, Le D, Watters J, Schreiber MA.
J Trauma Acute Care Surg. 2014 Jul;77(1):20-7; discussion 26-7.

The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study.​
Holcomb JB, Fox EE, Wade CE; PROMMTT Study Group.
J Trauma Acute Care Surg. 2013 Jul;75(1 Suppl 1):S1-2.