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Evolving Epidemiology of MOF into PICS

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Evolving Epidemiology of MOF into PICS
AAST Grand Round, February 18, 2015

Presented by:
Frederick A. Moore, MD, University of Florida, Gainesville

Moderated by:
Timothy Fabian, MD, University of Tennessee


Referenced in presentation:

Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
Gentile LF, Cuenca AG, Efron PA, Ang D, Bihorac A, McKinley BA, Moldawer LL, Moore FA.
J Trauma Acute Care Surg. 2012 Jun;72(6):1491-501.


The epidemiology of sepsis in general surgery patients.
Moore LJ, McKinley BA, Turner KL, Todd SR, Sucher JF, Valdivia A, Sailors RM, Kao LS, Moore FA.
J Trauma. 2011 Mar;70(3):672-80.


Validation of a screening tool for the early identification of sepsis.
Moore LJ, Jones SL, Kreiner LA, McKinley B, Sucher JF, Todd SR, Turner KL, Valdivia A, Moore FA.
J Trauma. 2009 Jun;66(6):1539-46; discussion 1546-7.


Postinjury multiple organ failure: a bimodal phenomenon.
Moore FA, Sauaia A, Moore EE, Haenel JB, Burch JM, Lezotte DC.
J Trauma. 1996 Apr;40(4):501-10; discussion 510-2.


Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure.
Botha AJ, Moore FA, Moore EE, Sauaia A, Banerjee A, Peterson VM.
J Trauma. 1995 Sep;39(3):411-7.


Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding.
Moore FA, Moore EE, Kudsk KA, Brown RO, Bower RH, Koruda MJ, Baker CC, Barbul A.
J Trauma. 1994 Oct;37(4):607-15.


TEN versus TPN following major abdominal trauma--reduced septic morbidity.
Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM.
J Trauma. 1989 Jul;29(7):916-22; discussion 922-3.


Benefits of immediate jejunostomy feeding after major abdominal trauma--a prospective, randomized study.
Moore EE, Jones TN.
J Trauma. 1986 Oct;26(10):874-81.


Further reading:

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
Vanzant EL, Lopez CM, Ozrazgat-Baslanti T, Ungaro R, Davis R, Cuenca AG, Gentile LF, Nacionales DC, Cuenca AL, Bihorac A, Leeuwenburgh C, Lanz J, Baker HV, McKinley B, Moldawer LL, Moore FA, Efron PA.
J Trauma Acute Care Surg. 2014 Jan;76(1):21-9; discussion 29-30.


Acute kidney injury is surprisingly common and a powerful predictor of mortality in surgical sepsis.
White LE, Hassoun HT, Bihorac A, Moore LJ, Sailors RM, McKinley BA, Valdivia A, Moore FA.
J Trauma Acute Care Surg. 2013 Sep;75(3):432-8.


Multiple organ failure can be predicted as early as 12 hours after injury.
Sauaia A, Moore FA, Moore EE, Norris JM, Lezotte DC, Hamman RF.
J Trauma. 1998 Aug;45(2):291-301; discussion 301-3.