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Controversies in Post-Injury Hemostasis

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Controversies in Post-Injury Hemostasis
AAST Grand Round, May 2014


Presented by:
Ernest E. Moore, MD

Moderated by:
Peter Rhee, MD


Referenced in presentation:

Hyperfibrinolysis, physiologic fibrinolysis, fibrinolysis shutdown: The spectrum of postinjury fibrinolysis and the relevance to antifibrinolytic therapy.
Moore HB, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A.
J Trauma Acute Care Surg. 2014 Dec;77(6):811-17.


Acquired coagulopathy of traumatic brain injury defined by routine laboratory tests: which laboratory values matter?
Joseph B, Aziz H, Zangbar B, Kulvatunyou N, Pandit V, O'Keeffe T, Tang A, Wynne J, Friese RS, Rhee P.
J Trauma Acute Care Surg. 2014 Jan;76(1):121-5.


A principal component analysis of coagulation after trauma.
Kutcher ME, Ferguson AR, Cohen MJ.
J Trauma Acute Care Surg. 2013 May;74(5):1223-9; discussion 1229-30.


Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy.
Ostrowski SR, Johansson PI.
J Trauma Acute Care Surg. 2012 Jul;73(1):60-6.


Characterization of platelet dysfunction after trauma.
Kutcher ME, Redick BJ, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Nelson MF, Cohen MJ.
J Trauma Acute Care Surg. 2012 Jul;73(1):13-9.


Impact of policy change on US Army combat transfusion practices.
Simmons JW, White CE, Eastridge BJ, Mace JE, Wade CE, Blackbourne LH.
J Trauma. 2010 Jul;69 Suppl 1:S75-80.


Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer?
Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A.
J Trauma. 2008 Aug;65(2):261-70; discussion 270-1.


Impact of plasma transfusion in massively transfused trauma patients.
Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P.
J Trauma. 2009 Mar;66(3):693-7.


The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital.
Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB.
J Trauma. 2007 Oct;63(4):805-13.


Damage control resuscitation: directly addressing the early coagulopathy of trauma.
Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR.
J Trauma. 2007 Feb;62(2):307-10.


Early massive transfusion [suppl].
J Trauma. 2006 June;60(6): S1-S96.


Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited.
Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B.
J Trauma. 1997 May;42(5):857-61; discussion 861-2.


The effect of hemorrhagic shock on the clotting cascade in injured patients.
Harrigan C, Lucas CE, Ledgerwood AM.
J Trauma. 1989 Oct;29(10):1416-21; discussion 1421-2.


Outcome of massive transfusion exceeding two blood volumes in trauma and emergency surgery.
Phillips TF, Soulier G, Wilson RF.
J Trauma. 1987 Aug;27(8):903-10.


Major abdominal vascular trauma—a unified approach.
Kashuk JL, Moore EE, Millikan JS, Moore JB.
J Trauma. 1982 Aug;22(8):672-9.