Aeromedical evacuation (AE) is often used as a rapid and effective way to evacuate patients. However, little is known about the possible effects of AE on patients with blast and traumatic brain injury. In the current study, we used blast overpressure (BOP) as a method to introduce traumatic brain injury in rats and investigated the effects of hypobaria during AE on histology and inflammatory response.
Animals were exposed to a 12-hour flight 2 days after BOP and euthanized 48 hours after flight. Control animals were kept at normobaria.
Overall, BOP animals exposed to flight demonstrated higher histopathologic injury scores as compared to control animals in lungs, brain, kidney, heart, and intestine. The BOP animals exposed to normobaria exhibited a proinflammatory response compared to those that were not blasted, an observation that was not seen in BOP animals exposed to hypobaria.
These data suggest that AE 48 hours post blast may lead to impairment in the inflammatory process and worsening of long-term outcomes.
Animal research, level II.
From the NeuroTrauma Department (Y.D., J.S., A.W., Y.C., F.A., C.G., D.M., A.H.S.), Naval Medical Research Center, Silver Spring; Henry M. Jackson Foundation for the Advancement of Military Medicine (Y.D., A.W., Y.C., F.A., D.M., A.H.S.); School of Medicine (J.S.); Department of Surgery (F.A., C.G., D.M., A.H.S.).Uniformed Services University of the Health Sciences, Bethesda; and Department of Pathology (M.A.J., D.M.), Walter Reed Army Institute of Research, Silver Spring, Maryland.
Submitted: November 30, 2018, Revised: January 8, 2019, Accepted: February 14, 2019, Published online: April 26, 2019.
This article will be presented (D. Malone) as an oral quick shot at the 32nd Annual Scientific Assembly for the Eastern Association for the Surgery of Trauma (EAST) held in Austin, TX from January 15 to 19, 2019.
Address for reprints: Yaron Dayani, PhD, NeuroTrauma Department Naval Medical Research Center 503 Robert Grant Avenue Silver Spring, MD 20910; email: firstname.lastname@example.org.
Online date: April 26, 2019