To standardize care and promote early fascial closure among patients undergoing emergent laparotomy and temporary abdominal closure (TAC), we developed a protocol addressing patient selection, operative technique, resuscitation strategies, and critical care provisions. We hypothesized that primary fascial closure rates would increase following protocol implementation with no difference in complication rates.
We performed a retrospective cohort analysis of 138 adult trauma and emergency general surgery patients who underwent emergent laparotomy and TAC, comparing protocol patients (n = 60) to recent historic controls (n = 78) who would have met protocol inclusion criteria. The protocol includes low-volume 3% hypertonic saline resuscitation, judicious wound vacuum fluid replacement, and early relaparotomy with sequential fascial closure. Demographics, baseline characteristics, illness severity, resuscitation course, operative management, and outcomes were compared. The primary outcome was fascial closure.
Baseline characteristics, including age, American Society of Anesthesiologists class, and postoperative lactate levels, were similar between groups. Within 48 hours of initial laparotomy and TAC, protocol patients received significantly lower total intravenous fluid resuscitation volumes (9.7 vs. 11.4 L, p = 0.044) and exhibited higher serum osmolarity (303 vs. 293 mOsm/kg, p = 0.001). The interval between abdominal operations was significantly shorter following protocol implementation (28.2 vs. 32.2 hours, p = 0.027). The incidence of primary fascial closure was significantly higher in the protocol group (93% vs. 81%, p = 0.045, number needed to treat = 8.3). Complication rates were similar between groups.
Protocol implementation was associated with lower crystalloid resuscitation volumes, a transient hyperosmolar state, shorter intervals between operations, and higher fascial closure rates with no difference in complications.
Therapeutic study, level IV.
From the Department of Surgery (T.J.L., P.A.E., T.M.B., M.D.R., C.A.C., M.S.W., R.S.S., F.A.M., A.M.M., S.C.B.), University of Florida Health, Gainesville, Florida; and Sepsis and Critical Illness Research Center (T.J.L., P.A.E., M.D.R., F.A.M., A.M.M., S.C.B.), University of Florida Health, Gainesville, Florida.
Submitted: June 30, 2018, Revised: July 31, 2018, Accepted: August 2, 2018, Published online: December 18, 2018.
This work has not been previously presented, and this manuscript is not under consideration elsewhere. This work will be presented at a poster session at the American College of Surgeons Clinical Congress 2018 in Boston, MA.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Address for reprints: Scott C. Brakenridge, MD, MSCS, University of Florida Health, 1600 SW Archer Rd, Room M-602, Gainesville, FL 32608; email: Scott.Brakenridge@surgery.ufl.edu.
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