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mRDH Bandage for Surgery and Trauma: Data Summary and Comparative Review

Valeri, C. Robert MD; Vournakis, John N. PhD

Journal of Trauma and Acute Care Surgery: August 2011 - Volume 71 - Issue 2 - p S162-S166
doi: 10.1097/TA.0b013e31822555e9
Review Article

Background: Bleeding often poses significant life-threatening situations to surgeons. After trauma, a one-third of civilian casualties and one-half of combat casualties die as a result of exsanguination. Recent advances have provided promising new hemostatic dressings that are applied directly to severely bleeding wounds in the pre-hospital period.

Methods: The modified Rapid Deployment Hemostat (mRDH) trauma/surgery bandage, containing fully acetylated, diatom-derived, poly-N-acetyl-glucosamine fibers, has a unique multifactorial hemostatic action that incorporates vasoconstriction, erythrocyte agglutination, and platelet and RBC activation.

Results: Animal studies have shown that the mRDH bandage quickly and completely stops both venous and arterial bleeding, even in the presence of a coagulopathy. A prospective study in humans is in accord with these findings.

Conclusion: The mRDH trauma/surgery bandage was able to increase survival of patients after high-grade liver trauma with an associated coagulopathy. Additional clinical studies support this result.

From the Naval Blood Research Laboratory, Inc. (C.R.V.), Boston, Massachusetts; and Marine Polymer Technologies, Inc. (J.N.V.), Burlington, Massachusetts.

Submitted for publication March 16, 2011.

Accepted for publication May 19, 2011.

Address for reprints: John N. Vournakis, PhD, Marine Polymer Technologies, Inc., 24 New England Executive Park, Suite 210, Burlington, MA 01803; email: johnv@webmpt.com.

© 2011 Lippincott Williams & Wilkins, Inc.