From the Department of Surgery (C.J.H.), Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts; Trauma Unit (K.B.), Johannesburg Hospital, University of the Witwatersrand, Johannesburg, South Africa; Department of Anesthesiology (R.D.), University of Maryland School of Medicine and R. Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, Maryland; Division of Allergy, Pulmonary and Critical Care Medicine (G.R.B.), Vanderbilt Coordinating Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Division of Trauma and Critical Care (M.A.C.), University of Tennessee Health Science Center, Memphis, Tennessee; Division of Acute Care Surgery and Center for Translational Injury Research (J.B.H.), University of Texas Health Science Center at Houston, Houston, Texas; Department of Surgery (A.L.), Meilahti Hospital, University of Helsinki, Finland; Intensive Care Unit (M.P.), Liverpool Hospital, University of New South Wales, Sydney, Australia; Department of Intensive Care (J.-L.V.), Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium; Novo Nordisk Inc. (B.J.T.), Princeton, New Jersey; Novo Nordisk A/S (J.D.), Bagsvaerd, Denmark; and Department of Trauma and Orthopedic Surgery (B.B.), University of Witten/Herdecke Cologne Merheim Medical Center, Cologne, Germany.
Submitted for publication December 1, 2009.
Accepted for publication June 21, 2010.
Supported by Novo Nordisk A/S, Bagsvaerd, Denmark (sponsor).
Dr. Jeannett Dimsits and Dr. Bartholomew Tortella are employees of Novo Nordisk. Dr. Carl J. Hauser received consulting fees from Novo Nordisk and grant support from NIH/NIGMS. Dr. Kenneth Boffard received consulting fees from Novo Nordisk. Dr. Richard Dutton received consulting fees from Novo Nordisk and grant support from Octapharma and the Department of Defense. Dr. Gordon R. Bernard received consulting fees and grant support from Novo Nordisk. Dr. Martin A. Croce received consulting fees from Novo Nordisk and grant support from Wyeth and EISAI. Dr. John B. Holcomb received consulting fees from Novo Nordisk and HEMCON. Dr. Ari Leppaniemi received consulting fees from Novo Nordisk. Dr. Michael Parr received consulting fees, lecture fees from Novo Nordisk, and grant support from Novo Nordisk and PPD. Dr. Jean-Louis Vincent received consulting fees and grant support from Novo Nordisk. Dr. Bertil Bouillon received consulting fees and lecture fees from Novo Nordisk. Dr. G. Howard received compensation as an independent consultant.
The sponsor was responsible for providing clinical trial supplies, preparing the study protocol, data management, statistical analysis, and preparing the clinical trial report. Anders Rosholm, PhD, is an employee of Novo Nordisk and assisted with the statistical analyses. Jen Faleska, PhD, and Charlotte Yap, MSc, are employees of Novo Nordisk and provided editorial assistance.
A copy of the CONTROL database has been made available for academic study by special arrangement with the Trauma Audit Research Network (TARN) at the University of Manchester, UK (Maralyn Woodford, Executive Director, +44 (0) 161 206 5952).
Presented at the 40th Annual Meeting of the Western Trauma Association, February 28–March 6, 2010, Telluride, Colorado.
Address for correspondence: Dr. Carl J. Hauser, Department of Surgery, Beth Israel Deaconess Medical Center, 110 Francis Street, LMOB 2-G, Boston, MA 02216; email: [email protected].