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Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: Patient-Oriented Research Core—Standard Operating Procedures for Clinical Care VII—Guidelines for Antibiotic Administration in Severely Injured Patients

West, Michael A. MD, PhD; Moore, Ernest E. MD; Shapiro, Michael B. MD; Nathens, Avery B. MD, PhD, MPH; Cuschieri, Joseph MD; Johnson, Jeffrey L. MD; Harbrecht, Brian G. MD; Minei, Joseph P. MD; Bankey, Paul E. MD, PhD; Maier, Ronald V. MDThe Inflammation and the Host Response to Injury Collaborative Research Program

The Journal of Trauma: Injury, Infection, and Critical Care: December 2008 - Volume 65 - Issue 6 - p 1511-1519
doi: 10.1097/TA.0b013e318184ee35
Procedures and Techniques

When the clinical decision to treat a critically ill patient with antibiotics has been made, one must attempt to identify the site of infection based on clinical signs and symptoms, laboratory or diagnostic radiology studies. Identification of site requires, examination of patient, inspection of all wounds, chest radiograph, and calculation of clinical pulmonary infection score if ventilated, obtaining blood cultures, urinalysis, and line change if clinical suspicion of central venous catheter (CVC) source. If it is impossible to identify site, obtain cultures from all accessible suspected sites and initiate empiric, broad spectrum antibiotics. If likely site can be identified answer these questions: Is intra-abdominal site suspected? Is pulmonary source of infection suspected? Is skin, skin structure or soft tissue site suspected? If yes, does the patient have clinical signs suspicion for necrotizing soft tissue infection (NSTI)? Is a CVC infection suspected? Risk factors for more complicated infections are discussed and specific antibiotic recommendations are provided for each type and severity of clinical infection. Decision to continue, discontinue and/or alter antibiotic/antimicrobial treatment should be based on the clinical response to treatment, diagnostic or interventional findings, and culture and sensitivity data, bearing in mind that not all patients with infections will have positive cultures because of limitations of specimen handling, microbiology laboratory variations, time between specimen acquisition and culture, or presence of effective antibiotics at the time that specimens were obtained. It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative.

From the Department of Surgery (M.A.W.), University of California, San Francisco, San Francisco, California, Department of Surgery (M.B.S.), Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Surgery (E.E.M., J.L.J.), University of Colorado, Denver, Colorado; Department of Surgery (A.B.N.), University of Toronto, Toronto, Ontario; Department of Surgery (J.C., R.V.M.), University of Washington, Seattle, Washington; Department of Surgery (B.G.H.), University of Louisville, Louisville, Kentucky; Department of Surgery (J.P.M.), University of Texas at Southwestern, Dallas, Texas; and Department of Surgery (P.E.B.), University of Rochester, Rochester, New York.

Submitted for publication December 3, 2007.

Accepted for publication May 30, 2008.

Supported by Large-Scale Collaborative Project Award (U54-GM62119) from The National Institute of General Medical Sciences, National Institutes of Health.

Address for correspondence: Michael A. West, MD, PhD, Department of Surgery, UCSF-San Francisco General Hospital, 1001 Potrero Avenue, Ward 3A, San Francisco, CA 94110; email:

© 2008 Lippincott Williams & Wilkins, Inc.