Article TitlesComparison of Poly-N-Acetyl Glucosamine with Commercially Available Topical Hemostats for Achieving Hemostasis in Coagulopathic Models of Splenic HemorrhageSchwaitzberg, Steven D. MD; Chan, Michele W. MD; Cole, David J. MD; Read, Marjorie PhD; Nichols, Timothy MD; Bellinger, David PhD; Connolly, Raymond J. PhDAuthor Information From the Department of Surgery, New England Medical Center (S.D.S., M.W.C., R.J.C.), Boston, Massachusetts, Department of Surgery, Medical University of South Carolina (D.J.C.), Charleston, South Carolina, and Department of Pathology and Laboratory Medicine, the Center for Thrombosis and Hemostasis, the Division of Laboratory Medicine, and the Department of Medicine, University of North Carolina at Chapel Hill (M.R., D.B., T.N.), Chapel Hill, North Carolina. Submitted for publication January 28, 2004. Accepted for publication February 20, 2004. Supported by grants and contracts from Marine Polymer Technologies, Inc., Danvers, Massachusetts. Presented, in part, at the Harvard University Department of Surgery Symposium, Clinical Activity and Mode of Action of the Hemostatic Agent Poly-N-Acetyl Glucosamine, February 25, 2003, Boston, Massachusetts. Address for reprints: Steven D. Schwaitzberg, MD, Department of Surgery, New England Medical Center, 25 Harvard Street, Boston, MA 02111; email: [email protected]. The Journal of Trauma: Injury, Infection, and Critical Care: July 2004 - Volume 57 - Issue 1 - p S29-S32 doi: 10.1097/01.TA.0000136747.35311.60 Buy Metrics Abstract Background: The hemostatic quality of the poly-N-acetyl glucosamine (p-GlcNAc) patch was compared with a fibrin sealant, fibrin bandage, and cellulose patch. Methods: A 2 × 2-cm capsular strip to a depth of 3 mm of the swine spleen was used as a source of bleeding. Splenic lacerations were created in hemophilia B dogs and treated with p-GlcNAc and Surgicel. Wounds were created in rabbits and treated with p-GlcNAc at 37°C and after keeping body core temperature at 29°C. Results: Poly-N-acetyl glucosamine was able to achieve hemostasis with greater efficacy than either of the fibrin-based bandages. In the hemophilia B dog study, p-GlcNAc significantly outperformed Surgicel, with p-GlcNAc achieving hemostasis in 75% of the treated wounds compared with 17% for the cellulose patch. The hypothermia study demonstrated that p-GlcNAc is equally effective at 29°C and at 37°C. Conclusion: Poly-N-acetyl glucosamine was effective at controlling bleeding in animals with experimentally induced or genetic coagulopathic disorders. © 2004 Lippincott Williams & Wilkins, Inc.