This is a systematic review and meta-analysis.
This study’s goal was to (i) assess the clinical outcomes with and without vertebral augmentation (VA) for osteoporotic vertebral compression fractures (VCFs) with versus without correlating signs and symptoms; and (ii) acute (symptoms <3 mo duration) and subacute VCFs (3–6 mo duration) versus chronic VCFs (>6 mo).
Previously, a randomized controlled trial in the New England Journal of Medicine concluded that vertebroplasty for osteoporotic VCFs provided no clinical benefit over sham surgery. However, the VCFs examined had no clinical correlation with symptom, physical examination, or imaging (magnetic resonance imaging/bone scan) findings. Nonetheless, the randomized controlled trial resulted in a reduction in VA performed in the United States. Currently, no consensus exists on VA versus nonoperative care for symptomatic VCFs (SVFs).
A literature search was conducted for studies on VA and conservative management for VCFs. Meta-analysis was performed using the random-effects model. The primary outcome was improvement in lower back pain visual analog score. SVFs were defined as radiographic VCF with clinical correlation. Radiographic-alone VCF (RVF) was defined as radiographic VCF without clinical correlation.
Thirteen studies totaling 1467 patients with minimum 6-month follow-up were found. Pain reduction was greater with VA over conservative management for SVFs (P<0.000001) and equivalent for RVFs (P=0.22). Subanalysis for acute/subacute SVFs and chronic SVFs showed that VA was superior to nonoperative care (P=0.0009 and 0.04, respectively). No difference was observed in outcomes between VA and nonoperative care for chronic RVF (P=0.22).
VA is superior to nonoperative care in reducing lower back pain for osteoporotic VCFs with correlating signs and symptoms. VA had no benefit over nonoperative care for chronic VCFs that lacked clinical correlation. Lower back pain has many etiologies and patients should be clinically assessed before recommending VA.
*Department of Orthopaedic Surgery, University of California
†School of Medicine, University of California, La Jolla, San Diego, CA
W.L. and C.C. contributed equally.
S.G.: AO North America: Research support; Benvenue Medical: Paid consultant; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Research support; EBI: Paid consultant; Research support; Elsevier: Publishing royalties, financial or material support; Globus Medical: Paid consultant; Research support; Harcourt: Publishing royalties, financial or material support; International Society for the Advancement of Spine Surgeons: Board or committee member; Intrinsic Therapeutics: Paid consultant; Journal of Bone and Joint Surgery—American: Editorial or governing board; Lippincott: Publishing royalties, financial or material support; Magnifi Group: Paid consultant; Medtronic: Research support; Mosby: Publishing royalties, financial or material support; Nuvasive: Paid consultant; Research support; SI Bone: Paid consultant; Stock or stock Options; SLACK Incorporated: Editorial or governing board; Spinal Kinetics: Paid consultant; Spine: Editorial or governing board; Synthes: Research support; Thieme Publishers: Publishing royalties, financial or material support; Vertiflex: Paid consultant; Wolters Kluwer Health—Lippincott Williams & Wilkins: Editorial or governing board; Publishing royalties, financial or material support. The remaining authors declare no conflict of interest
Reprints: Sina Pourtaheri, MD, UCSD Department of Orthopedic Surgery, 200 W. Arbor Drive #8894 San Diego, CA 92103-8894 (e-mail: firstname.lastname@example.org).
Received December 11, 2017
Accepted May 21, 2018