Experimental animal study.
The authors conducted a study to determine the effectiveness of waxed paper
in preventing postlaminectomy epidural fibrosis
Summary of Background Data
Extensive epidural fibrosis
after lumbar surgery may be the underlying cause in most cases of failed back surgery syndrome. Various materials have been used to prevent epidural fibrosis
, but only moderate success has been shown.
Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Waxed paper
was applied in a blinded fashion to the operative sites. In the control group, only the L-4 laminectomy
was performed. The rats were killed 28 days after surgery.
The extent of epidural fibrosis
was evaluated by histologic analysis. There was a meaningful statistical difference among the waxed paper
group and the Gore-Tex
group compared with the control group, but there was no difference when the effectiveness of waxed paper
was compared with that of Gore-Tex
In this experimental model, the waxed paper
applied locally effectively reduced epidural fibrosis
, completely avoided dural adherence, and induced no side effects.