REVIEW ARTICLEDo Artificial Food Colors Promote Hyperactivity in Children with Hyperactive Syndromes? A Meta-Analysis of Double-Blind Placebo-Controlled TrialsSCHAB, DAVID W. M.D., M.P.H.1; TRINH, NHI-HA T. M.D., M.P.H.2 Author Information 1Columbia University, Department of Psychiatry & The New York State Psychiatric Institute, New York, New York 2Harvard University, MGH/McLean Department of Psychiatry, Boston, Massachusetts Address for reprints: Dr. David W. Schab, New York State Psychiatric Institute, 1051 Riverside Drive Unit #84, New York, New York, 10032; e-mail: [email protected]. Journal of Developmental & Behavioral Pediatrics 25(6):p 423-434, December 2004. Buy Abstract Burgeoning estimates of the prevalence of childhood attention-deficit/hyperactivity disorder (ADHD) raise the possibility of a widespread risk factor. We seek to assess whether artificial food colorings (AFCs) contribute to the behavioral symptomatology of hyperactive syndromes. We searched ten electronic databases for double-blind placebo-controlled trials evaluating the effects of AFCs. Fifteen trials met the primary inclusion criteria. Meta-analytic modeling determined the overall effect size of AFCs on hyperactivity to be 0.283 (95% CI, 0.079 to 0.488), falling to 0.210 (95% CI, 0.007 to 0.414) when the smallest and lowest quality trials were excluded. Trials screening for responsiveness before enrollment demonstrated the greatest effects. Despite indications of publication bias and other limitations, this study is consistent with accumulating evidence that neurobehavioral toxicity may characterize a variety of widely distributed chemicals. Improvement in the identification of responders is required before strong clinical recommendations can be made. © 2004 Lippincott Williams & Wilkins, Inc.