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The Spectrum of Developmental Disability with Zika Exposure

What Is Known, What Is Unknown, and Implications for Clinicians

Gordon-Lipkin, Eliza MD*; Peacock, Georgina MD, MPH

Journal of Developmental & Behavioral Pediatrics: June 2019 - Volume 40 - Issue 5 - p 387–395
doi: 10.1097/DBP.0000000000000665
Special Article
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ABSTRACT: Clinicians who treat children with neurodevelopmental disabilities may encounter infants with congenital Zika syndrome or those exposed to Zika virus (ZIKV), either in utero or postnatally, in their practice and may have questions about diagnosis, management, and prognosis. In this special report, we reviewed the current literature to provide a comprehensive understanding of the findings and needs of children exposed to ZIKV in utero and postnatally. The current literature is sparse, and thus, this review is preliminary. We found that infants and children exposed to ZIKV in utero have a variety of health and developmental outcomes that suggest a wide range of lifelong physical and developmental needs. Postnatal exposure does not seem to have significant long-lasting health or developmental effects. We provide a comprehensive examination of the current knowledge on health and developmental care needs in children exposed to Zika in utero and postnatally. This can serve as a guide for health care professionals on the management and public health implications of this newly recognized population.

*Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD;

Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.

Address for reprints: Georgina Peacock, MD, Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Hwy MS-E88, Atlanta, GA 30329; e-mail: ghn3@cdc.gov.

Disclosure: The authors declare no conflict of interest.

The findings and conclusions in this publication are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Received September , 2018

Accepted February , 2019

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.