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Early Developmental Screening: Sensitivity and Specificity of Chronological and Adjusted Scores

PIPER MARTHA C. Ph.D.; PINNELL, LYNN E. M.N.; DARRAH, JOHANNA M.Sc. (P.T.); BYRNE, PAUL J. M.B., Ch.B., F.R.C.P.(C); WATT, M JOSEPH M.B., B.S., F.R.C.P.(C)
Journal of Developmental & Behavioral Pediatrics: April 1992
Original Articles: PDF Only

ABSTRACT.

The motor development of 75 preterm infants was assessed at 4 months chronological and 4 months adjusted ages using the Movement Assessment of Infants (MAI). Infants were followed until 18 months old when neurological and motor outcomes were assessed by a developmental pediatrician, and outcomes were classified as normal, suspicious, or abnormal. Sensitivity, specificity, and positive and negative predictive values were calculated at the two points in time using a variety of cutoff MAI scores. At 4 months, the practice of adjusting for prematurity resulted in the better combination of screening rates for the detection of both neurologically abnormal and neurologically abnormal/suspicious children. To obtain comparable rates, different cutoff MAI scores were used to identify the neurologically abnormal versus the neurologically abnormal/suspicious children. The optimal combination of sensitivity, specificity, positive and negative predictive values varies according to the age of assessment, the disorders being identified, and the cutoff scores employed. J Dev Behav Pediatr 13:95–101, 1992.

© Lippincott-Raven Publishers.