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Tobramycin-impregnated calcium sulfate pellets for the treatment of chronic osteomyelitis in children and adolescents

Andreacchio, Antonioa; Alberghina, Flaviaa; Paonessa, Matteoa; Cravino, Mattiaa; De Rosa, Vincenzob; Canavese, Federicoc

Journal of Pediatric Orthopaedics B: May 2019 - Volume 28 - Issue 3 - p 189–195
doi: 10.1097/BPB.0000000000000517

The aim of this work was to evaluate the outcome and efficacy of treatment in a homogeneous group of skeletally immature patients with chronic osteomyelitis of the long bones managed by a combination of radical debridement and insertion of tobramycin-impregnated calcium sulfate pellets to fill the bone defect in a single-stage procedure. Between 2011 and 2016, 12 skeletally immature patients were treated surgically by the reported technique. Single-stage surgery using tobramycin-impregnated calcium sulfate pellets in association with systemic antibiotic therapy yields satisfactory outcomes in skeletally immature children presenting chronic osteomyelitis by reducing the risk of occurrence of comorbidities, hospital stays, and healthcare costs.

aDepartment of Pediatric Orthopedic Surgery, Regina Margherita Children’s Hospital, Torino, Italy

bDepartment of Pediatric Orthopedics, Bellinzona e Valli Regional Hospital, Bellinzona, Switzerland

cDepartment of Pediatric Surgery, University Hospital Estaing, Clermont Ferrand, France

Correspondence to Federico Canavese, MD, PhD, Department of Pediatric Orthopedic, University Hospital Estaing, 1, Place Lucie et Raymond Aubrac, 63003 Clermont Ferrand, France Tel: +33 473 750 293; fax: +33 473 750 291; e-mail:

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