Mesenchymal stem cells as adjuvant therapy for limb lengthening in achondroplasiaMemeo, Antonioa; Verdoni, Fabioc; Ingraffia, Caterinaa; Rossi, Lauraa; Pedretti, Leopoldob; D’Amato, Raffaele D.a; Peretto, Lauraa; Mineo, Giuseppe V.bJournal of Pediatric Orthopaedics B: May 2019 - Volume 28 - Issue 3 - p 221–227 doi: 10.1097/BPB.0000000000000571 PEDIATRIC ORTHOPAEDICS IN ITALY: SPECIAL ISSUE Buy SDC Abstract Author InformationAuthors Article MetricsMetrics Staged leg lengthening allows achondroplastic dwarfs to reach nearly normal height, but it takes long periods of external fixation and it can be burdened by delayed unions. Between 2009 and 2013, eight achondroplastic dwarfs showed delayed unions in the callus formation during femoral lengthening stages in our institute. We performed in-situ injections of bone marrow-derived stem cell concentrates. Patients underwent monthly clinical and radiographic assessment for determination of the healing rate. All eight patients showed an improvement in the regenerated bone, with an average healing index of 23.1 days/cm (range: 18.7–23.8 days/cm). The complete recovery of the delayed consolidation took on an average of 5.2 months (range: 2–10 months). The use of cellular therapy in these patients could represent an innovative application. aDepartment of Pediatric Orthopaedics and Traumatology bIV Division of Orthopaedics and Traumatology, ‘Gaetano Pini’ Orthopaedic Institute cDepartment of Pediatric Orthopaedics and Traumatology, IRCCS ‘Galeazzi’ Orthopedic Institute, Milan, Italy Correspondence to Raffaele D. D’Amato, MD, Piazza A. Ferrari, 1, 20122 Milan, Italy Tel: +39 025 829 6335, fax: +39 025 829 6763; e-mail: email@example.com Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.