MISCELLANEOUSCongenital insensitivity to pain in one familySvec, Andreya; Feldinszka, Janab; Kokavec, MilanbAuthor Information a1st Department of Orthopaedics and Trauma Surgery bDepartment of Pediatric Orthopaedics, Comenius University Bratislava, Bratislava, Slovak Republic Correspondence to Andrey Svec, PhD, 1st Department of Orthopaedics and Trauma Surgery, Comenius University Bratislava, Ruzinovska 6, Bratislava 82606, Slovak Republic Tel: +42 124 823 4688; fax: +42 124 823 4595; e-mail: firstname.lastname@example.org Journal of Pediatric Orthopaedics B: July 2018 - Volume 27 - Issue 4 - p 369-374 doi: 10.1097/BPB.0000000000000418 Buy Metrics Abstract Congenital insensitivity to pain (CIP) is a rare autosomal recessive genetic disease caused by mutation in several different genes. The diagnosis requires the combined skills and cooperation of pediatricians, neurologists, radiologists, pathologists, and orthopedic surgeons. Orthopedic manifestations of CIP include delayed diagnosis of fractures, nonunions, Charcot arthropathy, avascular necrosis, osteomyelitis, joint dislocations, and heterotopic ossifications. We present case reports of two brothers with CIP with various orthopedic manifestations and methods of surgical treatment with 10 years of follow-up. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.