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Lymphoma with unusual manifestations resembling acute osteomyelitis in bilateral ankles of an 8-year-old boy: a case report

Lee, Han-Juna; Kim, Min-Kyua; Yun, Ki-Wookb; Cha, Young Jooc; Yoo, Won Joond; Jung, Ho-Joonga

Journal of Pediatric Orthopaedics B: March 2014 - Volume 23 - Issue 2 - p 139–143
doi: 10.1097/BPB.0b013e328364eb56

Early proper diagnosis of non-Hodgkin’s lymphoma is critical. However, without a high index of suspicion, the diagnosis can often be missed because of the nonspecific symptoms and normal plain radiographs. Further, non-Hodgkin’s lymphoma can be misdiagnosed as an infectious condition – such as osteomyelitis or septic arthritis – or as an inflammatory disease. The authors report a case of mature B-cell lymphoma of the small intestine or colorectal primary malignancy with peritoneal seeding and multiple bone metastases in an 8-year-old boy. This case report emphasizes the importance of a comprehensive approach with patients, including children with nonspecific symptoms, to orthopedic surgeons.

Departments of aOrthopaedic Surgery


cLabratory Medicine and Medical Device Clinical Trial Center, Chung-Ang University College of Medicine

dDepartment of Orthopaedic Surgery, Seoul National University Children’s Hospital, Seoul, Korea

Correspondence to Ho-Joong Jung, MD, Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, 224-1 Heukseok-dong, Dongjak-ku, Seoul 156-755, Korea Tel: +82 2 6299 1718; fax: +82 2 822 1710; e-mail:

© 2014 by Lippincott Williams & Wilkins, Inc.