LIMB RECONSTRUCTIONSkeletal growth patterns in hereditary multiple exostoses a natural historyClement, Nicholas David; Duckworth, Andrew D.; Baker, Alexander D.L.; Porter, Daniel E.Author Information Department of Orthopaedics and Trauma, The Royal Infirmary of Edinburgh, Little France, Edinburgh, UK Correspondence to Daniel E. Porter, FRCS Ed (Trauma and Orthopaedics), MD, Department of Orthopaedics and Trauma, The Royal Infirmary at Little France, Old Dalkeith Road, Edinburgh EH16 4SU, UK Tel: +44 0131 650 1000; fax: +44 0131 536 0924; e-mail: [email protected] Journal of Pediatric Orthopaedics B: March 2012 - Volume 21 - Issue 2 - p 150-154 doi: 10.1097/BPB.0b013e32834dd21f Buy Metrics Abstract Hereditary multiple exostoses (HME) is a commonly inherited musculoskeletal condition and is associated with a diminished stature. We demonstrated that adults with HME were significantly shorter when compared with a control group (P<0.001); preadolescents, however, were significantly taller than predicted (P=0.01). This was reflected by their height centile; 58% of the adults were under the 25th centile, whereas 53% of the preadolescence group were above the 75th centile. Stature was more severely affected in patients with an EXT1 mutation (P=0.008). This study illustrates a novel age-related growth pattern associated with HME, which is also affected by genotype. © 2012 Lippincott Williams & Wilkins, Inc.