REVIEW ARTICLEOrthopedic complications related to growth hormone therapy in a pediatric populationHaidar, Rachid K.a; Nasrallah, Mona P.b; Der-Boghossian, Asdghig H.c; Ghanem, Ismat B.dAuthor Information Departments of aSurgery bInternal Medicine/Pediatric and Adolescent Medicine cPhysiology, American University of Beirut dDepartment of Orthopaedic Surgery, Saint-Joseph University, Beirut, Lebanon Correspondence to Dr Rachid K. Haidar, MD, Chief Division of Orthopedic Surgery, Associate Professor of Clinical Orthopedic Surgery, Department of Surgery, American University of Beirut Medical Center, PO Box 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon Tel: +961 3310877; fax: +961 1366384; e-mail: firstname.lastname@example.org Journal of Pediatric Orthopaedics B: January 2011 - Volume 20 - Issue 1 - p 57-61 doi: 10.1097/BPB.0b013e32833ed967 Buy Metrics Abstract Since the introduction of recombinant growth hormone, its use has diversified and multiplied. Growth hormone is now the recommended therapy for a growing indication to all forms of short stature because of its direct and indirect role on bone growth. Hereby, we discuss the orthopedic complications associated with growth hormone treatment in pediatric patients. These complications include carpal tunnel syndrome, Legg–Calve–Perthes' disease, scoliosis, and slipped capital femoral epiphysis. Their incidence rates recorded in several growth hormone therapy-related pharmacovigilance studies will be summarized in this study with focused discussion on their occurrence in the pediatric and adolescent age groups. The pathogenesis of these complications is also reviewed. © 2011 Lippincott Williams & Wilkins, Inc.