Endoctine, Metabolic, and Liver Disorders: PDF OnlyNesidioblastosis: A Case StudyKistler, Caroline Hoell MSN, RN, CNNP1; Spiering, Kathleen MSN, RN, CNNP2 Author Information 1Neonatal Nurse Practitioner, Family Birthing Center, Jewish Hospital Kenwood 2Neonatal Nurse Practitioner, Family Birthing Center, Mercy Hospital Anderson, Cincinnati, Ohio The Journal of Perinatal & Neonatal Nursing: March 1998 - Volume 11 - Issue 4 - p 65-74 Buy Abstract Hypoglycemia is a frequent problem in the neonatal period requiring close attention and intervention. Severe, persistent hypoglycemia can have various etiologies; one of the most common causes is hyperinsulinism. Nesidioblastosis, although rare, is the most common cause of hyperinsulinism in the neonate. If not detected early, nesidioblastosis can lead to brain damage and death secondary to severe hypoglycemia. The etiology of nesidioblastosis remains unclear. Treatment involves maintaining normal blood glucose levels; treatment modalities include high glucose infusion rates, use of medications, and surgical intervention. The article reviews the pathophysiology and treatment modalities for nesidioblastosis. A case study is also presented that describes the clinical presentation, treatment, surgical intervention, and postdischarge clinical course of an infant with nesidioblastosis. © Williams & Wilkins 1998. All Rights Reserved.