FEATURE ARTICLESReducing Recurrent Preterm Births Best Evidence for Transitioning to Predictive and Preventative StrategiesCypher, Rebecca L. MSN, PNNPAuthor Information Department of OB-GYN, Madigan Healthcare System, Tacoma, Washington. Corresponding Author: Rebecca L. Cypher, MSN, PNNP, Department of OB-GYN, Madigan Healthcare System, Bldg 9040, Fitzsimmons Dr, Tacoma, WA 98431 ([email protected]). Disclaimer: The views expressed are those of the author and do not reflect the official policy of the Department of the Army, the Department of Defense or the US Government. Disclosure: The author has disclosed that she has no significant relationships with, or financial interest in, any commercial companies pertaining to this article. She is a member of Ther-X Advisory Panel for Makena. Submitted for publication: March 8, 2012; accepted for publication: May 23, 2012. The Journal of Perinatal & Neonatal Nursing: July/September 2012 - Volume 26 - Issue 3 - p 220-229 doi: 10.1097/JPN.0b013e3182611b9e Buy Metrics Abstract Women who have delivered an infant between 16 and 36 weeks' gestation have an increased risk of preterm birth (PTB) in a subsequent pregnancy. The high incidence of recurrent PTB remains relatively unchanged despite intensive research efforts and advances in perinatal care. Attempts to decrease the incidence of recurrent PTB have not always been successful, with research efforts being focused on clinical, pharmacotherapy and biochemical, and ultrasound strategies. Fortunately, there is adequate evidence in the literature to justify clinical management guidelines that may impact the PTB rate: smoking cessation, treatment of asymptomatic bacteriuria, transvaginal ultrasonography of the cervix, administration of vaginal progesterone or 17α-hydroxyprogesterone caproate, cerclage, and fetal fibronectin. This article is intended to give brief highlights of these strategies and the current science that supports their conclusions. Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.